PMID: 6987514Apr 10, 1980Paper

Association of MB compatibility with successful intrafamilial kidney transplantation

The New England Journal of Medicine
René J DuquesnoyH M Kauffman

Abstract

The MB system is a newly defined system of B-cell alloantigens closely associated with HLA-DR. We assessed the role of MB compatibility in renal transplantation in a retrospective study of 21 patients who had received a kidney transplant from a related donor matched for a single HLA haplotype. One-year transplant survival was closely correlated with the presence of a compatibile MB antigen in the unshared haplotype of the donor: Eight of eight rejected kidneys were obtained from MB-incompatible donors, and 12 of 13 successful transplants were from MB-compatible donors. The association between MB compatibility and allograft acceptance was highly significant (P = 4.4 x 10(-5)), but no significant relation could be demonstrated between transplant survival and donor-recipient compatibility for antigens of the HLA-A, B or DR loci. These findings suggest that match matching for MB may be critical for the selection of donors in intrafamilial kidney transplantation.

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Citations

Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·E W PetersdorfJ A Hansen
Nov 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J H Helderman, P Gailiunas
Jan 1, 1994·Transfusion Medicine Reviews·P G Beatty
Dec 18, 2004·Human Immunology·Steve TakemotoRene J Duquesnoy
Jan 1, 1985·The Journal of Surgical Research·C M Zmijewski
Jan 1, 1982·Immunological Reviews·D A ShackelfordJ L Strominger
Oct 27, 2016·Pediatric Transplantation·Rene J Duquesnoy
Sep 1, 1982·Immunology Today·K Guy, V Van Heyningen
Jan 1, 1982·Immunological Reviews·P J Morris, A Ting
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·C M Zmijewski

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