Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients

International Journal of Immunogenetics
C B FilhoSérgio Crovella

Abstract

We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.

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Citations

Dec 7, 2018·Genetics and Molecular Biology·Luana Oliveira Dos SantosNeide Santos
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Fei ShenBo Xu

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