Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome

International Journal of Endocrinology and Metabolism
Bercem Aycicek DoganSerdar Guler

Abstract

Mean platelet volume (MPV) is generally accepted as a new marker of cardiovascular disease risk in several studies. This study aimed to determine the association of MPV with androgen hormones and insulin resistance (IR) in nonobese patients with polycystic ovary syndrome (PCOS). A total of 136 patients with newly diagnosed reproductive-age PCOS (regarding the criteria of new PCOS phenotypes, based on the Rotterdam criteria) who were nonobese with the mean age of 25 years (25.39 ± 5.51) and mean body mass index (BMI) of 21 kg/m(2) (22.07 ± 2.13) were included. In addition, 59 healthy subjects with mean age of 26 years (22.07 ± 2.13) and mean BMI of 22 kg/m(2) (21.52 ± 3.84) were recruited as control. Total blood count (including MPV), total testosterone, free testosterone, dehydroepiandrosterone-sulfate (DHEAS), and androstenedione levels were recorded. IR was calculated from blood chemistry measurements of fasting insulin and glucose according to updated homeostasis model assessment. No differences were observed in mean MPV values between patients and control group (9.02 fL (8.5-10.1) and 8.9 fL (7.7-9.1), respectively; P = 0.777). MPV values were similar among nonobese patients with and without IR and control subjects (P > 0.0...Continue Reading

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Citations

Mar 17, 2016·Journal of Endocrinological Investigation·Y ÇakıroğluB Vural
May 16, 2014·Fertility and Sterility·Andrea MorcianoRosanna Apa
Apr 8, 2017·Andrologia·Irmak Sayin, Mustafa Kadihasanoglu

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