Association of Menopausal Age with Unruptured Intracranial Aneurysm Morphology

Interventional Neurology
Sushrut DharmadhikariDileep Yavagal

Abstract

The prevalence of unruptured intracranial aneurysms (UIAs) increases rapidly in aging women compared with younger women. The impact of menopausal age on UIAs and treatment outcomes with endovascular therapy has not been well studied. We hypothesized that premenopausal age may have a protective effect on presentation size and treatment outcomes. To evaluate the association of menopause with UIA size and outcome with endovascular therapy. Retrospective analysis of consecutive female patients with UIAs treated with endovascular therapy at our academic tertiary care center. UIA characteristics, complications, and outcomes were recorded and compared. 117 patients were included: 23 patients in the premenopausal age (PRM) group and 94 in the postmenopausal age (POM) group. 93.6% of all aneurysms in the PRM group were in the internal carotid artery (ICA) segments (p < 0.05). Hence only ICA segment aneurysms were further studied. A total of 21 patients in the PRM group and 60 in the POM group were found to have ICA segment aneurysms. Baseline characteristics were similar between the 2 groups. The mean size of the aneurysms in the PRM group was 8.6 ± 3.9 versus 10.8 ± 5.6 mm in the POM group (p = 0.055). There was a trend to higher aneur...Continue Reading

References

Aug 1, 1994·Annals of Internal Medicine·W T LongstrethG van Belle
Mar 23, 1999·Journal of Clinical Epidemiology·I KatoA Zeleniuch-Jacquotte
Jul 18, 2003·Lancet·David O WiebersUNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
Sep 1, 2006·The New England Journal of Medicine·Jonathan L BrismanDavid W Newell
Jun 29, 2012·The New England Journal of Medicine·Akio MoritaTakashi Yoshimoto
Feb 21, 2013·Stroke; a Journal of Cerebral Circulation·Monique H M VlakAle Algra
Feb 19, 2015·Stroke; a Journal of Cerebral Circulation·Laura C SijtsmaYnte M Ruigrok

❮ Previous
Next ❯

Citations

Nov 25, 2020·Antioxidants·Wei-Cheng JiangShaw-Fang Yet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.