Association of Metabolic Syndrome and Inflammation with Cognitive Decline in Adults Aged 60 Years and Older: Findings from a National Health Survey in the United States

Neuroscience Journal
Zuolu Liu, Carol F Lippa

Abstract

Objectives. We aimed to test the hypothesis that metabolic syndrome (MetS) is significantly associated with cognitive decline (CoD) in elderly adults and further assess whether MetS and inflammation have a significant joint effect on CoD. Methods. Data (n = 2975) from the U.S. National Health and Nutrition Examination Survey (1999-2002) in participants aged ≥60 years who had Digit Symbol Substitution Tests (DSS: a standard measure of cognitive function) were studied. CoD was defined as those in the lowest quintile of DSS score. MetS was defined as having ≥3 of 5 MetS traits (large waist circumference (WC), high blood pressure (BP), elevated glucose, triglycerides, and decreased high density lipoprotein cholesterol). Results. Of 2975 participants, the prevalence of CoD (DSS score <25) was 12.1%. After adjusting covariates, individual large WC, high BP, elevated glucose level, and MetS were significantly associated with CoD in logistic regression models (P < 0.001). There was a significant dose-response relationship between an increased number of MetS traits and CoD (P < 0.001). A significant joint effect of MetS and CRP on the odds of CoD was observed. Conclusion. The study, using a nationally representative sample, extended pre...Continue Reading

References

Aug 20, 2003·Archives of Neurology·Liesi E HebertDenis A Evans
Feb 14, 2006·Clinical Cornerstone·Abu R Vasudevan, Christie M Ballantyne
Aug 19, 2006·Progress in Neurobiology·Lars P van der HeideMarten P Smidt
Sep 14, 2007·Clinical Pharmacology and Therapeutics·J A BatsisF Lopez-Jimenez
Jul 9, 2008·Journal of Clinical and Experimental Neuropsychology·Ronald A CohenMarie Gerhard-Herman
Jan 23, 2009·The Biochemical Journal·Susan Broughton, Linda Partridge
Mar 26, 2010·Nature·Nicholas A BishopBruce A Yankner
May 7, 2010·Ageing Research Reviews·Vincenza FrisardiFrancesco Panza
Jun 24, 2010·Journal of Alzheimer's Disease : JAD·Francesco PanzaVincenzo Solfrizzi
Mar 4, 2011·International Journal of Geriatric Psychiatry·Whitney J DickinsonDavid C Steffens
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Kathy F YatesAntonio Convit
Dec 19, 2012·Journal of Alzheimer's Disease : JAD·Liang FengTze Pin Ng

❮ Previous
Next ❯

Citations

Sep 8, 2020·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Jessica StrongElizabeth Leritz
Nov 20, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Catherine M BenderKirk I Erickson

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.