Association of Metformin Use with Outcomes in Advanced Endometrial Cancer Treated with Chemotherapy

PloS One
Obiageli EzewuiroIris L Romero

Abstract

There is increasing evidence that metformin, a commonly used treatment for diabetes, might have the potential to be repurposed as an economical and safe cancer therapeutic. The aim of this study was to determine whether stage III-IV or recurrent endometrial cancer patients who are using metformin during treatment with chemotherapy have improved survival. To test this we analyzed a retrospective cohort of subjects at two independent institutions who received chemotherapy for stage III-IV or recurrent endometrial cancer from 1992 to 2011. Diagnosis of diabetes, metformin use, demographics, endometrial cancer clinico-pathologic parameters, and survival duration were abstracted. The primary outcome was overall survival. The final cohort included 349 patients, 31 (8.9%) had diabetes and used metformin, 28 (8.0%) had diabetes but did not use metformin, and 291 (83.4%) did not have diabetes. The results demonstrate that the median overall survival was 45.6 months for patients with diabetes who used metformin compared to 12.5 months for patients with diabetes who did not use metformin and 28.5 months for patients without diabetes (log-rank test comparing the three groups P = 0.006). In a model adjusted for confounders, the difference i...Continue Reading

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Citations

Dec 17, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rashmi R Shah
Apr 30, 2017·Molecular and Clinical Oncology·Emi SatoSatoru Kyo
Sep 14, 2018·Frontiers in Oncology·Teresa Y LeeJennifer M Johnson
Sep 5, 2018·Journal of Translational Medicine·Christian Ramos-PeñafielAdolfo Martínez-Tovar
Aug 28, 2020·International Journal of Molecular Sciences·Satoru Kyo, Kentaro Nakayama
Dec 23, 2017·Biological Chemistry·Stephen SafeKeshav Karki
May 14, 2020·Cancers·Frances L ByrneRhonda Farrell
Dec 20, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah J KitsonEmma J Crosbie
Nov 11, 2021·Journal of Drug Targeting·Bartłomiej BarczyńskiJan Kotarski

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Methods Mentioned

BETA
xenograft
hysterectomy

Software Mentioned

Stata
Research Electronic Data Capture ( REDCap )

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