Association of methylenetetrahydrofolate reductase T677 allele with early development of chronic allograft nephropathy

Clinical Biochemistry
Ondrej ViklickýStefan Vítko

Abstract

The aim of this study was to evaluate the role of genetic polymorphisms on the development of chronic allograft nephropathy (CAN). Using the polymerase chain reaction (PCR), polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T), interleukin-6 (IL-6 G-174C) and CD14 (C-260T) were evaluated in 92 kidney transplant recipients with stable renal graft function and no signs of acute rejection in a protocol that included graft biopsy at 12 months after kidney transplantation. A normal population sample (n = 365) was also included. Multivariate analysis was used to evaluate the effect of different variables on the CAN appearance. There were no differences in alleles and genotypes distribution between transplant group and normal population sample. The CAN+ group (n = 69) significantly differed from CAN- (n = 23) in both MTHFR (P < 0.05) and IL-6 (P < 0.01) genotype distribution. Using logistic regression multivariate analysis, MTHFR T677 allele (OR: 3.91, CI: 1.11-13.8; P < 0.05), patient age (OR: 0.94, CI: 0.88-0.98; P < 0.01) and proteinuria (OR: 3.63, CI: 1.25-10.6; P < 0.05) were associated with CAN. Although the IL-6 G-174 allele was shown to be associated with CAN development in univariate analysis (P < 0.01), the mul...Continue Reading

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Citations

Aug 4, 2006·Molecular Diagnosis & Therapy·Faisal KhanSuraksha Agrawal
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Jul 15, 2015·Clinical Biochemistry·Jana StojanovaNicolas Picard

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