Association of microRNA-126 expression with clinicopathological features and the risk of biochemical recurrence in prostate cancer patients undergoing radical prostatectomy.

Diagnostic Pathology
Xiaoke SunBaoli Jing

Abstract

Numerous studies have suggested that microRNA-126 (miR-126) is involved in development of various cancer types as well as in malignant proliferation and invasion. However, its role in human prostate cancer (PCa) is still unclear. The aim of this study was to investigate miR-126 expression in PCa and its prognostic value for PCa patients undergoing radical prostatectomy. A series of 128 cases with PCa were evaluated for the expression levels of miR-126 by quantitative reverse-transcription PCR (qRT-PCR). Kaplan-Meier analysis and Cox proportional hazards regression models were used to investigate the correlation between miR-126 expression and prognosis of PCa patients. Compared with non-cancerous prostate tissues, the expression level of miR-126 was significantly decreased in PCa tissues (PCa vs. non-cancerous prostate: 1.05 ± 0.63 vs. 2.92 ± 0.98, P < 0.001). Additionally, the loss of miR-126 expression was dramatically associated with aggressive clinical pathological features, including advanced pathological stage (P = 0.001), positive lymph node metastasis (P = 0.006), high preoperative PSA (P = 0.003) and positive angiolymphatic invasion (P = 0.001). Moreover, Kaplan-Meier survival analysis showed that PCa patients with low ...Continue Reading

References

Aug 5, 2006·Urologia Internationalis·Joseph MolitiernoRaj S Pruthi
Aug 13, 2008·Developmental Cell·Jason E FishDeepak Srivastava
Jan 1, 2009·Biochemical and Biophysical Research Communications·Yoshimasa SaitoGangning Liang
Feb 19, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Bo LiuYong-Wen Qin
May 14, 2009·Journal of Experimental & Clinical Cancer Research : CR·Tao YuXin-zhu Yi
Oct 19, 2010·TheScientificWorldJournal·Jeannette Meister, Mirko H H Schmidt
Oct 26, 2011·Expert Review of Molecular Diagnostics·Lorenzo F Sempere
Nov 16, 2011·Seminars in Oncology·Francesca LovatCarlo M Croce
Nov 9, 2012·Clinical Chemistry·Konstantinos MavridisAndreas Scorilas
Jan 31, 2013·BMJ : British Medical Journal·Timothy J Wilt, Hashim U Ahmed
Feb 5, 2013·Clinical & Experimental Metastasis·Hongyuan ChenZhihai Peng
Feb 13, 2013·Current Opinion in Oncology·Damali N MartinStefan Ambs
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Dragan IlicPhilipp Dahm
Mar 21, 2013·Current Opinion in Oncology·Gary R MacVicar, Maha H Hussain
Mar 23, 2013·Current Opinion in Oncology·Howard L ParnesJoseph A Tangrea
Jun 13, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A MarkouE Lianidou
Jun 20, 2013·Journal of Cancer·Beatriz A WalterMaria J Merino
Jul 24, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian-Qiang XuXiao-Yi Ding
Aug 7, 2013·Molecular and Cellular Biology·Alexander de GiorgioLeandro Castellano

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Citations

Nov 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Elham TafsiriMorteza Karimipoor
Mar 14, 2016·Cellular and Molecular Life Sciences : CMLS·Valentina DoldiNadia Zaffaroni
Dec 18, 2015·Molecular Medicine Reports·Lei SongLongkai Peng
Nov 3, 2017·Journal of Cellular Biochemistry·Chun-Jiao SongQian-Nan Ding

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Methods Mentioned

BETA
PCR
reverse-transcription PCR

Software Mentioned

SPSS

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