PMID: 2499271Apr 1, 1989Paper

Association of mineral composition of neonatal intravenous feeding solutions and metabolic bone disease of prematurity

Archives of Disease in Childhood
P MacMahonI Z Kovar

Abstract

To assess the effects of increasing the mineral content of parenteral nutrition solutions on the biochemical and radiological indicators of metabolic bone disease of prematurity 27 neonates who required parenteral nutrition were sequentially allocated to receive either a standard solution (group 1) or one with an increased mineral content (group 2). The 13 patients in group 1 received 0.68 mmol/kg/day of calcium and 0.61 mmol/kg/day of phosphorus, and the 14 in group 2 received 1.25 and 1.20 mmol/kg/day, respectively. The two groups did not differ significantly in the severity of their illness measured by birth weight, gestational age, duration of parenteral nutrition or ventilation, or the amount of supplementary oxygen required. In patients in group 2 the median plasma phosphate concentration was higher, the plasma alkaline phosphatase activity was lower, and there was less radiological evidence of rickets. There were no complications caused by excess calcium and phosphorus, and the rate of growth was similar in both groups. We conclude that an increased mineral content in parenteral nutrition solutions reduces the severity of metabolic bone disease in sick infants who require this form of nutrition.

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Citations

Jan 1, 1992·Nutrition Research Reviews·J B Morgan, I Z Kovar
Oct 1, 1991·Journal of the American College of Nutrition·W W Koo, R C Tsang
Mar 16, 2006·Journal of the American College of Nutrition·Joyce C WongPhilippe Chessex
Apr 1, 1990·Archives of Disease in Childhood·P MacMahonI Z Kovar
Apr 1, 1990·Archives of Disease in Childhood·P MacMahonI Z Kovar
Mar 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·S Ryan
Aug 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·J FaerkK F Michaelsen
Apr 1, 1990·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·I Z Kovar, J B Morgan
Oct 1, 1993·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·H DevliegerE Eggermont
Feb 26, 2000·Clinics in Perinatology·F R Greer
Aug 23, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A L Buchman, A Moukarzel
Jul 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·W W Koo
Jul 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·W W Koo
Dec 30, 2009·Journal of Pediatric Gastroenterology and Nutrition·Timothy A SentongoAlan L Buchman
Mar 1, 1991·Annals of Clinical Biochemistry·P D Mayne, I Z Kovar

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