Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone

JAMA Network Open
Masaki ShiotaMasatoshi Eto

Abstract

Recently, genetic polymorphism in HSD3B1 encoding 3β-hydroxysteroid dehydrogenase-1 has been shown to be associated with oncological outcome when treated with androgen-deprivation therapy (ADT) for prostate cancer. Upfront abiraterone combined with ADT has proved survival benefit. However, its effect on oncological outcome among different ethnicities and in abiraterone treatment remain unclear. To investigate the significance of missense polymorphism in HSD3B1 gene among men treated with primary ADT or abiraterone. This prognostic study included Japanese patients with metastatic hormone-sensitive prostate cancer between June 1993 and July 2005 and with castration-resistant prostate cancer between September 2014 and February 2018. Genome DNA was obtained from patient whole blood samples, and genotyping on HSD3B1 (rs1047303, 1245C) was performed by Sanger sequencing. Primary ADT for metastatic hormone-sensitive prostate cancer and abiraterone for castration-resistant prostate cancer. The association of genotype in HSD3B1 with clinicopathological parameters and oncological outcome, including prostate-specific antigen response, progression-free survival, treatment failure-free survival, and overall survival was examined. Of 203 men...Continue Reading

References

Mar 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard I ScherUNKNOWN Prostate Cancer Clinical Trials Working Group
Apr 2, 2009·Cancer Control : Journal of the Moffitt Cancer Center·Laurens HolmesXianglin L Du
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Jul 15, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Masaki ShiotaSeiji Naito
Dec 21, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ShiotaM Eto
Jun 6, 2017·The New England Journal of Medicine·Karim FizaziUNKNOWN LATITUDE Investigators
Jun 6, 2017·The New England Journal of Medicine·Nicholas D JamesUNKNOWN STAMPEDE Investigators
Jun 26, 2018·The Journal of Clinical Investigation·Mohammad AlyamaniNima Sharifi

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Citations

Oct 16, 2019·Annual Review of Medicine·Richard J Auchus, Nima Sharifi
Jan 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Joe ZeinNima Sharifi
Jan 29, 2020·Expert Review of Molecular Diagnostics·Roberto IacovelliGiampaolo Tortora
Nov 4, 2020·Cancer Chemotherapy and Pharmacology·Fei-Fei HanLi-Hong Liu
Jan 17, 2021·Prostate Cancer and Prostatic Diseases·Takayuki SumiyoshiAlexander W Wyatt
Dec 30, 2020·Journal of Pharmaceutical and Biomedical Analysis·Thaís Luise Dillenburg WeissSimone Gasparin Verza
Jan 23, 2021·Endocrine Reviews·Kunal DesaiNima Sharifi
Mar 12, 2021·Nature Reviews. Urology·Yao ZhuDingwei Ye
Aug 20, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elahe A MostaghelR Bruce Montgomery

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Methods Mentioned

BETA
genotyping
PCR
biopsy

Software Mentioned

Sequence Scanner
JMP
SAS

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