Abstract
Schizophrenia and bipolar disorder share common genetic background. Several loci such as 18p11, 13q32, and 22q11-13 were commonly linked with these diseases. Since mitochondrial dysfunction has been suggested in both of these disorders, NDUFV2 at 18p11, encoding a subunit of the complex I, NADH ubiquinone oxidoreductase, is a candidate gene for these diseases. We previously reported that single nucleotide polymorphisms (SNPs) in the upstream region of NDUFV2 were associated with bipolar disorder in Japanese. The association of haplotype consisting of two SNPs, -3542G > A and -602G > A, with bipolar disorder was also seen both in Japanese and the National Institute of Mental Health Pedigrees trios. In this study, 2 polymorphisms, -3542G > A and -602G > A, were investigated in 229 schizophrenic patients as compared with controls. Individual genotypes were not associated with schizophrenia. However, the haplotype consisting of these two SNPs were significantly associated with schizophrenia. These results suggested that inter-individual variation of the genomic sequence of the promoter region of NDUFV2 might be a genetic risk factor common to bipolar disorder and schizophrenia.
References
Nov 22, 1995·Biochemical and Biophysical Research Communications·N HattoriY Mizuno
Apr 10, 1995·Genomics·R de CooB van Oost
Jan 1, 1993·Journal of Affective Disorders·T KatoT Inubushi
Sep 1, 1996·Neurochemical Research·S A WhatleyR M Marchbanks
Nov 14, 1997·Biological Psychiatry·T KatoR R Crowe
Aug 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J A PrinceL Oreland
Feb 22, 2000·Biological Psychiatry·W H Berrettini
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Feb 27, 2001·Journal of Affective Disorders·T KatoN Kato
Mar 21, 2001·Bipolar Disorders·T Kato, N Kato
Mar 30, 2001·Schizophrenia Research·I MaurerH Möller
Apr 4, 2001·The International Journal of Neuropsychopharmacology·Dorit Ben-ShacharEhud Klein
Oct 24, 2001·Molecular Psychiatry·T Kato
Nov 7, 2001·Journal of Bioenergetics and Biomembranes·J SmeitinkL van den Heuvel
Apr 2, 2002·The American Journal of Psychiatry·Alastair G CardnoPeter McGuffin
Oct 26, 2002·Molecular Psychiatry·N DrorD Ben-Shachar
Dec 11, 2002·Journal of Neurochemistry·Dorit Ben-Shachar
Jun 13, 2003·American Journal of Human Genetics·Ricardo SeguradoNurten Akarsu
Jun 13, 2003·American Journal of Human Genetics·Cathryn M LewisTomas Helgason
Jun 20, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shinsuke WashizukaTadafumi Kato
Mar 3, 2004·Archives of General Psychiatry·Christine KonradiStephan Heckers
Mar 10, 2004·International Review of Neurobiology·Dorit Ben-Shachar, Daphna Laifenfeld
Mar 25, 2004·Biological Psychiatry·Rachel KarryDorit Ben Shachar
Apr 21, 2004·Molecular Psychiatry·S PrabakaranS Bahn
Sep 29, 2004·Biological Psychiatry·Shinsuke WashizukaTadafumi Kato
Nov 26, 2004·Human Molecular Genetics·Kazuya IwamotoTadafumi Kato
Mar 15, 2005·Bipolar Disorders·Shinsuke WashizukaTadafumi Kato
Jul 27, 2005·Molecular Psychiatry·T KatoT Yoshikawa
Citations
Sep 29, 2009·Journal of Neural Transmission·Dorit Ben-Shachar
Nov 7, 2009·European Child & Adolescent Psychiatry·Regina TaurinesClaudia Mehler-Wex
Sep 10, 2008·Journal of Molecular Neuroscience : MN·Dorit Ben-ShacharGalila Agam
Jan 30, 2013·Psychiatry Research·Julia MorenoNoé Alvarado-Vásquez
May 16, 2012·Molecular Psychiatry·M AyalewA B Niculescu
Mar 19, 2011·Psychiatry and Clinical Neurosciences·Jana Hroudová, Zdeněk Fišar
Nov 8, 2008·PloS One·Dorit Ben-Shachar, Rachel Karry
Mar 18, 2009·PloS One·Brandi RollinsMarquis P Vawter
Jun 9, 2015·Scientific Reports·Xiao LiYong-Gang Yao
Oct 26, 2010·Parkinsonism & Related Disorders·Kenya NishiokaMatthew J Farrer
Jun 28, 2016·Molecular Neurobiology·Hong LiYong-Gang Yao
Nov 5, 2016·Journal of Proteome Research·Artur T KopylovAlexander I Archakov
May 19, 2017·Cellular and Molecular Life Sciences : CMLS·Toshifumi Fukuda, Shigeru Yanagi
Dec 28, 2006·CNS Drugs·Tadafumi Kato
Jul 15, 2016·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Oded Bergman, Dorit Ben-Shachar
Mar 29, 2007·Molecular Psychiatry·J G MulleA E Pulver
Sep 30, 2016·World Journal of Psychiatry·Eyal Asor, Dorit Ben-Shachar
Oct 11, 2007·Molecular Psychiatry·G KaroutzouD E Dietrich
Aug 14, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rebecca E S AnglinPatricia I Rosebush
Feb 19, 2009·Journal of Neuroscience Research·L SieE K Tan
Jan 18, 2008·Bipolar Disorders·Chun XuJerry J Warsh
May 11, 2016·Scientific Reports·Jingchun ChenUNKNOWN FTND meta-analysis group
Sep 14, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hayley B ClayChristine Konradi
Sep 1, 2012·Psychiatric Genetics·Liang MaXiaogang Chen
Dec 12, 2018·Molecular Psychiatry·Oded BergmanDorit Ben-Shachar
Jun 22, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Arvin HaghighatfardZakieh Ghadimi
Apr 18, 2017·Experimental and Therapeutic Medicine·Shujie GanJingdong Tang
Mar 23, 2021·Brain Research·Nitya Subrahmanian, Matthew J LaVoie
Mar 15, 2011·Biological Psychiatry·Marina RosenfeldDorit Ben-Shachar
Dec 31, 2010·Behavioral and Brain Functions : BBF·Wen ZhangYong-Gang Yao
Aug 19, 2021·Human Mutation·Yoshihito KishitaYasushi Okazaki