Association of mitochondrial DNA variations with lung cancer risk in a Han Chinese population from southwestern China.

PloS One
Shizhen ZhengFuyun Ji

Abstract

Mitochondrial DNA (mtDNA) is particularly susceptible to oxidative damage and mutation due to the high rate of reactive oxygen species (ROS) production and limited DNA-repair capacity in mitochondrial. Previous studies demonstrated that the increased mtDNA copy number for compensation for damage, which was associated with cigarette smoking, has been found to be associated with lung cancer risk among heavy smokers. Given that the common and "non-pathological" mtDNA variations determine differences in oxidative phosphorylation performance and ROS production, an important determinant of lung cancer risk, we hypothesize that the mtDNA variations may play roles in lung cancer risk. To test this hypothesis, we conducted a case-control study to compare the frequencies of mtDNA haplogroups and an 822 bp mtDNA deletion between 422 lung cancer patients and 504 controls. Multivariate logistic regression analysis revealed that haplogroups D and F were related to individual lung cancer resistance (OR = 0.465, 95%CI = 0.329-0.656, p<0.001; and OR = 0.622, 95%CI = 0.425-0.909, p = 0.014, respectively), while haplogroups G and M7 might be risk factors for lung cancer (OR = 3.924, 95%CI = 1.757-6.689, p<0.001; and OR = 2.037, 95%CI = 1.253-3.31...Continue Reading

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Citations

Feb 19, 2014·International Journal of Molecular Sciences·Hezhi FangYidong Bai
May 29, 2012·Free Radical Biology & Medicine·Shizhen ZhengFuyun Ji
May 12, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ruijie ZhangJianping Xu
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Nov 17, 2020·Frontiers in Genetics·Dayan SunXiaofeng Wang
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Mar 7, 2021·Mitochondrion·María Del Mar GonzálezMaria Pilar Aluja

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

- Phylogeny
Mitomap
Statistical Package for Social Science

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