Association of MMP3-1171(5A>6A) polymorphism with lung cancer in Lebanon

Genetic Testing and Molecular Biomarkers
Hana M A FakhouryRajaa Makki

Abstract

Matrix metalloproteinases (MMPs) are a family of enzymes that degrade extracellular matrix components and are involved in the development and progression of cancer. Lung cancer is the most commonly diagnosed cancer in Lebanon. This study was undertaken to investigate the association between -1171(5A>6A) polymorphism in the promoter of MMP3 gene and the susceptibility to lung cancer in a Lebanese population. The MMP3 polymorphism was investigated in 41 lung cancer patients and 51 unrelated healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. We found a significant association between MMP3-1171 5A allele and lung cancer (Odds ratio [OR]=2.7, 95% [CI]=1.3-5.3; Fisher's p-value=0.005). This study may form an additional evidence for the association of MMP3 enzyme and genetic susceptibility to lung cancer.

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Citations

Dec 24, 2014·American Journal of Respiratory and Critical Care Medicine·Anja SchmallRajkumar Savai
Mar 19, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Hassan R Dhaini, Loulou Kobeissi
Dec 3, 2014·Archives of Oral Biology·Ticiana M SabóiaMarcelo C Costa
May 15, 2021·Mediators of Inflammation·Vladimira DurmanovaIvana Shawkatova

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Methods Mentioned

BETA
PCR

Software Mentioned

MedCalc

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