Association of morbid obesity with disability in early inflammatory polyarthritis: results from the Norfolk Arthritis Register.

Arthritis Care & Research
J H HumphreysD P M Symmons

Abstract

Obesity has been associated with disease outcomes in inflammatory arthritis. This study aimed to investigate cross-sectionally the relationship between body mass index (BMI) and functional disability in a large inception cohort of patients with early inflammatory polyarthritis (IP). Patients age ≥16 years with ≥2 swollen joints for ≥4 weeks were recruited into the Norfolk Arthritis Register. At the initial assessment, clinical and demographic data were obtained, joints were examined, and height and weight were measured. Blood samples were taken to measure inflammatory markers and autoantibodies, and patients completed the Health Assessment Questionnaire (HAQ) to assess functional disability. Univariate and multivariate ordinal regression were used to examine the cross-sectional association between BMI and the HAQ. Multiple imputation using chained equations allowed inclusion of patients with missing variables. A total of 1,246 patients were studied (median age 57 years). Of those patients, 782 patients (63%) were female and 303 (25%) were obese (BMI ≥30 kg/m(2) ). Morbid obesity (BMI ≥35 kg/m(2) ) was significantly associated with worse functional disability in the univariate and multivariate analysis with missing data imputed,...Continue Reading

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Citations

Nov 23, 2013·Current Rheumatology Reports·Laura-Isabel ArranzCayetano Alegre
Jun 19, 2014·Zeitschrift für Rheumatologie·K Albrecht
May 8, 2014·International Journal of Rheumatic Diseases·Frank MoIneke C Neutel
Jul 6, 2014·The Journal of Rheumatology·Janet G DiffinSuzanne M M Verstappen
Jun 1, 2020·Arthritis Care & Research·Joshua F BakerKaleb Michaud

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