Association of MTOR and AKT Gene Polymorphisms with Susceptibility and Survival of Gastric Cancer

PloS One
Ying PiaoYuan Yuan

Abstract

The phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, AKT)/mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in angiogenesis and cell growth, proliferation, metabolism, migration, differentiation, and apoptosis. Genetic diversity in key factors of this pathway may influence protein function and signal transduction, contributing to disease initiation and progression. Studies suggest that MTOR rs1064261 and AKT rs1130233 polymorphisms are associated with risk and/or prognosis of multiple cancer types. However, this relationship with gastric cancer (GC) remains unclear. The aim of this study was to investigate the role of MTOR and AKT polymorphisms in the risk and prognosis of GC. The Sequenom MassARRAY platform was used to genotype 1842 individuals for MTOR rs1064261 T→C and AKT rs1130233 G→A polymorphisms. ELISA was used to detect Helicobacter pylori antibodies in serum. Immunohistochemical analysis was used to detect total and phosphorylated MTOR and AKT proteins. The MTOR rs1064261 (TC+CC) genotype and the AKT rs1130233 (GA+AA) genotype were associated with increased risk of GC in men (P = 0.049, P = 0.030). In H. pylori-negative individuals, the AKT rs1130233 GA and (GA+AA) genotypes were rela...Continue Reading

References

Apr 30, 1998·Current Opinion in Cell Biology·J Downward
Jun 11, 1999·Genes & Development·A C GingrasN Sonenberg
Apr 12, 2001·Genes & Development·A C GingrasN Sonenberg
Sep 27, 2001·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·M Stolte, A Meining
May 9, 2002·Molecular and Cellular Biology·Bangyan StilesHong Wu
Oct 11, 2002·Advances in Cancer Research·Kathleen A Martin, John Blenis
Nov 9, 2002·European Journal of Biochemistry·Gareth J Browne, Christopher G Proud
Jan 28, 2004·Nature Genetics·Effat S EmamianJoseph A Gogos
Nov 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sandra L HarrisArnold J Levine
Nov 17, 2005·Oncogene·Deborah A Altomare, Joseph R Testa
Feb 13, 2008·British Medical Bulletin·Paul Lochhead, Emad M El-Omar
Nov 11, 2008·The Journal of Biological Chemistry·Masaaki NakayamaToshiya Hirayama
Dec 25, 2008·Methods in Molecular Biology·Hermann BrennerVolker Arndt
Jul 15, 2009·Advances in Cancer Research·Bing-Hua Jiang, Ling-Zhi Liu
Nov 4, 2009·International Journal of Oncology·Qian XuRachel W Li
Jan 5, 2010·The Tohoku Journal of Experimental Medicine·Hajime IsomotoToshiya Hirayama
May 5, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y H GongY Yuan
Aug 12, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kristin A MoyJian-Min Yuan
Apr 6, 2011·Molecular and Cellular Neurosciences·Karan P SangheraShelley R Boyd
May 4, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I TramacereP Boffetta
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 16, 2011·Journal of Surgical Oncology·Min Jung KimJae Yong Park
Oct 14, 2011·The American Journal of Clinical Nutrition·Eric J DuellCarlos A González
Feb 21, 2013·Journal of Nanoscience and Nanotechnology·Zeeshan AliChao Ma
Mar 26, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mei-Ling ZhuQing-Yi Wei
Sep 3, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Zhiquan HuangWeiliang Chen
Oct 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qianxia LiZhongxing Liao
Apr 17, 2014·Journal of Cancer Research and Clinical Oncology·Xiaoting WangFeng Zheng
May 23, 2014·Virchows Archiv : an International Journal of Pathology·Oscar TapiaJuan Carlos Roa
Jul 26, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yun WangQianming Chen
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I TramacereP Boffetta

❮ Previous
Next ❯

Citations

Jan 7, 2017·Trends in Microbiology·Michael NaumannSteffen Backert
Apr 23, 2020·Molecular Biology Reports·Mohsen SaravaniMohammad Hadi Nematollahi
Feb 28, 2019·Cancer Research·Mengqiu SongMee-Hyun Lee
Feb 12, 2020·Genes & Diseases·Fateme Sadat EshaghiMajid Ghayour-Mobarhan
Jan 31, 2021·European Journal of Pharmacology·Jian WangLing Ding
Mar 2, 2021·European Journal of Pharmacology·Ayda Baghery Saghchy KhorasaniDavood Bashash

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Makoto NakaoHideo Tanaka
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jing-Jing JingYuan Yuan
© 2021 Meta ULC. All rights reserved