Association of Myocardial Blood Flow Reserve With Adverse Left Ventricular Remodeling in Patients With Aortic Stenosis: The Microvascular Disease in Aortic Stenosis (MIDAS) Study.

JAMA Cardiology
Wunan ZhouMarcelo Di Carli

Abstract

Impaired myocardial flow reserve (MFR) and stress myocardial blood flow (MBF) on positron emission tomography (PET) myocardial perfusion imaging may identify adverse myocardial characteristics, including myocardial stress and injury in aortic stenosis (AS). To investigate whether MFR and stress MBF are associated with LV structure and function derangements, and whether these parameters improve after aortic valve replacement (AVR). In this single-center prospective observational study in Boston, Massachusetts, from 2018 to 2020, patients with predominantly moderate to severe AS underwent ammonia N13 PET myocardial perfusion imaging for myocardial blood flow (MBF) quantification, resting transthoracic echocardiography (TTE) for assessment of myocardial structure and function, and measurement of circulating biomarkers for myocardial injury and wall stress. Evaluation of health status and functional capacity was also performed. A subset of patients underwent repeated assessment 6 months after AVR. A control group included patients without AS matched for age, sex, and summed stress score who underwent symptom-prompted ammonia N13 PET and TTE within 90 days. MBF and MFR quantified on ammonia N13 PET myocardial perfusion imaging. LV s...Continue Reading

References

Feb 20, 2007·Journal of the American College of Cardiology·Farhad BakhtiaryPeter Kleine
Feb 22, 2012·JACC. Cardiovascular Imaging·Christopher D SteadmanGerry P McCann
Dec 25, 2013·European Heart Journal·Filippo CreaCathleen Noel Bairey Merz
Oct 12, 2017·European Heart Journal·Philippe GénéreuxMartin B Leon
Feb 24, 2018·Journal of the American College of Cardiology·Thomas A TreibelJames C Moon
Jun 20, 2018·Circulation. Cardiovascular Imaging·Russell J EverettMarc R Dweck
Oct 5, 2018·JAMA Cardiology·Patrizio LancellottiCécile Oury
May 3, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wunan ZhouMarcelo Di Carli
Feb 26, 2020·Nature Reviews. Cardiology·Marc DeweyUNKNOWN Quantitative Cardiac Imaging Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.