Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study.

The International Journal of Cardiovascular Imaging
Deborah H KwonMilind Y Desai

Abstract

Patients with hypertrophic cardiomyopathy (HCM) are predisposed to ventricular tachyarrhythmia (VT); likely due to myocardial fibrosis or disarray. Delayed hyperenhancement magnetic resonance imaging (DHE-MRI) accurately detects myocardial fibrosis (scar). We sought to determine the association between septal thickness, myocardial scar and VT. Sixty-eight patients (mean age 44 years, 69% males) with documented HCM underwent cine MRI (Siemens Sonata or Avanto 1.5 T scanner, Erlangen, Germany) in short axis, 2, 3 and 4-chamber views and maximal interventricular septal thickness was recorded at end-diastole. Corresponding DHE-MR images (8-10 mm thick) were obtained, approximately 20 min after injection of 0.2 mmol/kg of Gadolinium. Scar was determined semi-automatically (as % of total myocardium) using VPT software (Siemens) and defined as intensity >2 SD above viable myocardium in a 12 segment short-axis model at apex, mid LV and base. Presence of VT (documented on ambulatory ECG monitoring) and history of sudden death were recorded. One patient had a history of sudden death and 9 (13%) had VT on ambulatory ECG monitoring. On DHE-MRI, 39 (57%) patients had myocardial scar. Patients with VT had significantly higher scar %, compare...Continue Reading

References

Aug 1, 1990·Journal of the American College of Cardiology·B J Maron
Jan 1, 1990·American Journal of Epidemiology·C A Boyle, P Decouflé
Sep 1, 1986·Journal of the American College of Cardiology·B J MaronW C Roberts
Jul 1, 1985·Journal of the American College of Cardiology·B J MaronS E Epstein
Jan 10, 1980·The New England Journal of Medicine·F G CosioA Liovet
Jul 17, 1996·JAMA : the Journal of the American Medical Association·B J MaronF O Mueller
Mar 13, 1997·The New England Journal of Medicine·P SpiritoB J Maron
May 1, 1997·Journal of the American Medical Informatics Association : JAMIA·T B Newman, A N Brown
Sep 14, 1999·Journal of the American College of Cardiology·M S LauerE J Topol
Dec 29, 2000·Journal of the American College of Cardiology·P M ElliottW J McKenna
Jul 27, 2001·The American Journal of Cardiology·A M VarnavaW J McKenna
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Barry J Maron
Dec 31, 2002·Journal of the American College of Cardiology·Lubna ChoudhuryRaymond J Kim
May 14, 2003·Journal of the American College of Cardiology·James C C MoonDudley J Pennell
Sep 26, 2003·Journal of Magnetic Resonance Imaging : JMRI·Randolph M SetserRichard D White
Mar 11, 2004·Magnetic Resonance Imaging·Kunihiko TeraokaAkira Yamashina
Jun 15, 2004·Journal of the American College of Cardiology·James C C MoonDudley J Pennell
Mar 1, 2005·Journal of the American College of Cardiology·A Selcuk AdabagBarry J Maron
Jul 15, 2005·The International Journal of Cardiovascular Imaging·Arunark KolipakaRandolph M Setser

❮ Previous
Next ❯

Citations

Oct 31, 2009·The International Journal of Cardiovascular Imaging·F D SantiagoE C de Faria
Jun 1, 2008·Journal of Cardiovascular Translational Research·Daniel P Judge, Nicole M Johnson
Jun 19, 2010·Journal of Cardiovascular Translational Research·Martin S Maron
Aug 26, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jamshid Shirani, Vasken Dilsizian
May 16, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Etienne M AliotUNKNOWN Heart Rhythm Society
Feb 3, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Martin S Maron
Feb 22, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Radwa A NoureldinDavid A Bluemke
Jan 9, 2010·The International Journal of Cardiovascular Imaging·Anil K AttiliRob J van der Geest
Nov 10, 2010·The International Journal of Cardiovascular Imaging·E E van der WallM J Schalij
Apr 9, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·I A W van RijsingenY M Pinto
Feb 23, 2010·The International Journal of Cardiovascular Imaging·E E van der Wall, M J Schalij
Oct 24, 2014·Radiology·Jan Bogaert, Iacopo Olivotto
Mar 30, 2010·The International Journal of Cardiovascular Imaging·Mateusz SpiewakWitold Ruzyłło
Sep 28, 2010·The International Journal of Cardiovascular Imaging·Elif ElmasTheano Papavassiliu
Oct 13, 2010·Current Cardiology Reports·Milind Y DesaiAndrew C Y To
Dec 20, 2012·Current Cardiology Reports·Theodoros D Karamitsos, Stefan Neubauer
Dec 21, 2010·Heart Failure Reviews·Mouaz H Al-Mallah, Mohammad Naseem Shareef
Aug 21, 2015·Pediatric Cardiology·Laure LégerYvan Mivelaz
Jun 13, 2012·Progress in Cardiovascular Diseases·Seth Uretsky
Apr 26, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehUNKNOWN Society of Cardiovascular Computed Tomography
May 26, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Martin S Maron, Natesa G Pandian
Aug 25, 2009·The American Journal of Cardiology·Georgios K EfthimiadisGeorgios E Parcharidis
Dec 2, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Zoran B PopovićMilind Y Desai
Feb 14, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuki HenTetsuya Sumiyoshi
May 24, 2015·Cardiac Electrophysiology Clinics·Kartik R KumarMark S Link
Feb 2, 2010·Journal of the American College of Cardiology·Georgios K Efthimiadis, Efstathios D Pagourelias
Aug 7, 2010·Journal of the American College of Cardiology·Rory O'HanlonSanjay K Prasad
Jul 6, 2010·Journal of the American College of Cardiology·Michael Salerno, Christopher M Kramer
Oct 3, 2009·Journal of the American College of Cardiology·Theodoros D KaramitsosStefan Neubauer
Sep 1, 2012·Journal of the American College of Cardiology·David A Bluemke, Eunice Yang
Mar 1, 2015·Clinical Imaging·David M NaegerKaren G Ordovas
Oct 18, 2011·JACC. Cardiovascular Imaging·Andrew C Y ToMilind Y Desai
Apr 14, 2012·JACC. Cardiovascular Imaging·John J GreenMichael Salerno
Jul 3, 2016·European Heart Journal·Adaya Weissler-SnirHarry Rakowski
Dec 18, 2009·Expert Review of Cardiovascular Therapy·Deborah H Kwon, Milind Y Desai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.