Association of neopterin as a marker of immune system activation and juvenile rheumatoid arthritis activity

Jornal de pediatria
Mones M Abu ShadyGihan A Fathy

Abstract

To evaluate neopterin plasma concentrations in patients with active juvenile idiopathic arthritis (JIA) and correlate them with disease activity. Sixty patients diagnosed as active JIA, as well as another 60 apparently healthy age- and gender-matched children as controls, were recruited from the Pediatrics Allergy and Immunology Clinic, Ain Shams University. Disease activity was assessed by the Juvenile Arthritis Disease Activity Score 27 (JADAS-27). Laboratory investigations were performed for all patients, including determination of hemoglobin concentration (Hgb), erythrocyte sedimentation rate (ESR), and C-reactive protein. Serum concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and neopterin were measured. Significant differences were found between JIA patients and controls with regard to the mean levels of Hgb, ESR, TNF-α, IL-6, and MCP-1 (p<0.05). A statistically significant higher mean level serum neopterin concentration (p<0.05) was found in JIA patients (20.43±8.73 nmol/L) than in controls (6.88±2.87 nmol/L) (p<0.05). Positive significant correlations were detected between serum neopterin and ESR, TNF-α, IL-6, MCP-1, and JADAS-27 (p<0.05). No correl...Continue Reading

References

Sep 25, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G HoffmannD Fuchs
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katharina SchroecksnadelDietmar Fuchs
Aug 12, 2005·Current Opinion in Rheumatology·Alexa Adams, Thomas J A Lehman
Aug 10, 2006·Current Opinion in Rheumatology·James D Phelan, Susan D Thompson
Apr 9, 2008·Arthritis Research & Therapy·Annette H M van der Helm-van Mil, Tom W J Huizinga
May 1, 2009·Arthritis and Rheumatism·Alessandro ConsolaroUNKNOWN Paediatric Rheumatology International Trials Organisation
Jun 13, 2009·Arthritis Research & Therapy·Sherine E Gabriel, Kaleb Michaud
Oct 27, 2009·Best Practice & Research. Clinical Rheumatology·Berent J Prakken, Salvatore Albani
Jul 14, 2010·Annals of Internal Medicine·Tom W J Huizinga, Theodore Pincus
Jan 11, 2011·Korean journal of pediatrics·Youn-Soo Hahn, Joong-Gon Kim
May 11, 2011·Clinical Rheumatology·Yesim OzkanBolkan Simsek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.