Association of neprilysin polymorphism with cerebral amyloid angiopathy

Journal of Neurology, Neurosurgery, and Psychiatry
M YamadaH Mizusawa

Abstract

The risk of sporadic cerebral amyloid angiopathy (CAA) may be associated with genetic polymorphisms of molecules related to anabolism or catabolism of amyloid beta protein (Abeta). The authors investigated whether a polymorphism of the gene (NEP) coding for neprilysin, an enzyme catabolising Abeta, is associated with CAA. The study analysed the GT repeat polymorphism in the enhancer/promoter region of NEP and severity of CAA in 164 necropsied elderly Japanese subjects. The subjects had NEP polymorphisms with 19 to 23 GT repeats and were classified into nine genotypes. CAA severity was significantly higher in the subjects with up to 40 repeats in total than those with more than 40 repeats (p=0.005). There was a significant correlation between the number of the shorter alleles (19 or 20 repeats) and CAA severity (p=0.024). In addition, there was no interaction between the NEP polymorphism and apolipoprotein E genotype. These results suggest the association between the NEP polymorphism and the risk of CAA. Further study using more samples from populations with different ethnic backgrounds is necessary.

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Citations

May 9, 2013·Brain Research·Maximilian GahrCarlos Schönfeldt-Lecuona
Aug 24, 2010·Acta Pharmacologica Sinica·Jin-min GuoDing-feng Su
Mar 31, 2009·Journal of Neurotrauma·Victoria E JohnsonDouglas H Smith
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·T HamaguchiM Yamada
Jan 2, 2010·Neurosurgical Focus·Efthimios DardiotisGeorgios M Hadjigeorgiou
May 27, 2009·International Journal of Molecular Sciences·Samir Kumar-Singh
Jan 29, 2010·Neuroscience Letters·Kathrin HuehneAndreas Winterpacht
Sep 22, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Yu-Wei ChenEric E Smith
Mar 28, 2008·Brain Pathology·James Scott MinersSeth Love
Apr 15, 2006·Brain Pathology·Martin C HerzigMathias Jucker
Nov 13, 2004·Journal of the Neurological Sciences·Masahito Yamada
Dec 16, 2016·Nature Reviews. Cardiology·Duncan J Campbell
May 11, 2017·Cardiovascular Therapeutics·Chayakrit Krittanawong, Takeshi Kitai
May 31, 2016·F1000Research·Lewis BussAndré Strydom
Feb 19, 2015·Journal of Stroke·Masahito Yamada

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