Association of neurofascin IgG4 and atypical chronic inflammatory demyelinating polyneuropathy: A systematic review and meta-analysis

Brain and Behavior
Wenyu HuYinan Zhao

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most commonly observed phenotype among chronic acquired demyelinating polyneuropathies and is clinically variable. The aim of this meta-analysis was to evaluate the diagnostic value and characteristics of CIDP targeting neurofascin 155 (NF155). A systematic literature search was performed on March 2018, and two reviewers independently extracted data and assessed the risk of bias on MEDLINE, EMBASE, the Web of Science, and the Cochrane Library to identify relevant articles. Ten articles for the NF155 protein test with 1,161 patients and 1,636 controls were identified. The results showed that the pooled sensitivity was 0.09 (95% CI: 0.06-015), and specificity was 1.00 (95% CI: 0.98-1.00) of the NF155 for CIDP. The meta-analysis revealed that the sensory ataxic occurrence rate (OR: 10.79, 95% CI: 5.24-22.22) and tremor occurrence rate (OR: 6.71, 95% CI: 3.37-13.39) were higher among patients positive for NF155 compared with NF155-negative CIDP patients. However, the rate of good treatment response to intravenous immunoglobulin (IVIg) (OR: 0.09, 95% CI: 0.02-0.42) was lower in NF155-positive CIDP patients. NF155 is a specific protein marker for CIDP, but its di...Continue Reading

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Citations

Jul 16, 2019·Current Opinion in Neurology·Elba Pascual-GoñiLuis Querol
May 21, 2020·Annals of Clinical and Translational Neurology·Diamantis AthanasopoulosKalliopi Pitarokoili
May 29, 2020·Neurology. Neuroimmunology and Neuroinflammation·Divyanshu DubeyAndrew McKeon
Feb 28, 2020·Neurology·Lorena Martín-AguilarLuis Querol
Nov 7, 2020·Brain : a Journal of Neurology·Filip EftimovCamiel Verhamme
Jun 21, 2020·Journal of Neuroimmunology·Li JiaoShougang Guo
Mar 31, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ze WangYangtai Guan
Jul 31, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Peter Y K Van den BerghHaluk A Topaloglu
Nov 4, 2021·Neurology. Neuroimmunology and Neuroinflammation·Lorena Martín-AguilarLuis Querol

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Methods Mentioned

BETA
ELISA
biopsies

Software Mentioned

RevMan
STATA
PRISMA

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