Association of neuropeptide W, but not obestatin, with energy intake and endocrine status in Zucker rats. A new player in long-term stress-feeding interactions

Appetite
Bernard BeckGrégory Pourié

Abstract

The aim of this study was to ascertain the roles of neuropeptide W (NPW) and obestatin in feeding and endocrine regulations and their interactions with leptin, corticosterone, and insulin, three key hormones involved in metabolic homeostasis. Plasma variations were measured in obese hyperphagic Zucker rats either following a one-day fast, or after chronic food restriction (one-third less food than normal for three weeks). Obestatin did not vary by feeding condition, and did not differ between lean and obese rats; it likely does not play any role in feeding regulation. NPW did not vary with one-day fasting, but was higher in obese rats than in lean rats under satiated (+38%) and fasting (+44%; P<0.01) conditions. In chronically food-restricted obese rats that lost about 10% of their initial body weight, NPW decreased by 18% (P<0.02), in parallel with a similar decrease in plasma insulin (P<0.03), and a 10% decrease of plasma leptin (P<0.001). Corticosterone levels in obese rats were much higher than in lean rats, and increased (P<0.0001) after chronic food restriction, but not after a short fast. Prolonged food restriction was therefore stressful for obese rats. Long-term food shortage associated with insulin, leptin and cortico...Continue Reading

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Citations

Oct 2, 2014·Peptides·Hui LiAmanda J Page
Mar 21, 2013·Journal of Animal Physiology and Animal Nutrition·T NasoA El-Kirdasy
Feb 19, 2015·Journal of Molecular Neuroscience : MN·Fumiko TakenoyaSeiji Shioda
Apr 18, 2013·Brain Research Bulletin·Nadezhda Bazhan, Dóra Zelena
Apr 5, 2017·Acta Physiologica·H LiA J Page
Aug 9, 2018·Frontiers in Physiology·Magdalena Chottova Dvorakova

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