Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications

PloS One
Daniela P LeonardoMaria Laura Costa

Abstract

Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality in the world, but its appearance is still unpredictable and its pathophysiology has not been entirely elucidated. Genetic studies have associated single nucleotide polymorphisms in genes encoding nitric oxide synthase and matrix metalloproteases with preeclampsia, but the results are largely inconclusive across different populations. To investigate the association of single nucleotide polymorphisms (SNPs) in NOS3 (G894T, T-786C, and a variable number of tandem repetitions VNTR in intron 4), MMP2 (C-1306T), and MMP9 (C-1562T) genes with preeclampsia in patients from Southeastern Brazil. This prospective case-control study enrolled 77 women with preeclampsia and 266 control pregnant women. Clinical data were collected to assess risk factors and the presence of severe complications, such as eclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. We found a significant association between the single nucleotide polymorphism NOS3 T-786C and preeclampsia, independently from age, height, weight, or the other SNPs studied, and no association was found with the other polymorphisms. Age and history of preeclampsia were a...Continue Reading

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Citations

Jul 21, 2017·International Journal of Molecular Sciences·Salvador Espino Y SosaGuadalupe Estrada-Gutierrez
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Jul 3, 2021·Journal of Clinical Medicine·Marwa Ben Ali GannounJulie L Lavoie

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Methods Mentioned

BETA
genotyping
electrophoresis

Software Mentioned

R
Excel
GraphPad
GraphPad Prism
epicalc
SNPassoc

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