Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population

Journal of Medical Virology
Juan MaYing Liu

Abstract

Natural killer (NK) cells are important antiviral effectors of innate immunity because of their contribution to virus elimination. NK cell-mediated immunological reaction to hepatitis B virus (HBV) infection depends on a fine balance between inhibitory and activating receptors. The aim of the study was to investigate genetic polymorphisms in NK cell receptors (NKR)-KLRD1 (CD94), KLRK1 (NKG2D), KLRC4 (NKG2F), and KLRC1 (NKG2A)-to evaluate the association of NKR genetic polymorphisms with susceptibility to chronic hepatitis B in a Han Chinese population. Twelve single nucleotide polymorphisms (SNPs), including rs2302489 in CD94; rs2255336, rs2617160, rs7980470, rs 2734565, and rs17513986 in NKG2D; rs2617170, rs17549004, and rs3825295 in NKG2F; rs2734414, rs7301582, and rs2734440 in NKG2A, were selected in the present study. SNP genotyping was undertaken in 500 Han Chinese patients (285 patients with chronic hepatitis B and 215 patients who cleared HBV spontaneously) by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and by the TaqMan method. Single marker association analysis was conducted and the SNP rs2617160 with a TT genotype in NKG2D was associated significantly with an increased risk of chron...Continue Reading

References

Jun 8, 1999·Annual Review of Immunology·C A BironT P Salazar-Mather
Jun 22, 2000·Journal of Medical Virology·W C Maddrey
Oct 4, 2000·The Journal of Experimental Medicine·K KakimiF V Chisari
Mar 18, 2004·Reviews in Medical Virology·Hisashi Arase, Lewis L Lanier
May 14, 2004·Molecular Immunology·Dae-Ki KimJohn E Coligan
Jul 20, 2004·Immunologic Research·Anasuya GunturiJames Forman
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
May 16, 2006·Human Immunology·Robert A EagleJohn Trowsdale
Mar 14, 2007·The Journal of Experimental Medicine·Claire DunnMala K Maini
Nov 6, 2007·Seminars in Liver Disease·Gyongyi SzaboAngela Dolganiuc
Jan 15, 2008·Immunologic Research·Steven J BurgessJohn E Coligan
Sep 3, 2008·Journal of Gastroenterology and Hepatology·Amitis RamezaniAli Akbar Velayati
Jan 16, 2009·The New England Journal of Medicine·Juan Miguel BerguaHelena Bañas
Jan 17, 2009·Cancer Letters·I Chemin, F Zoulim
Feb 4, 2009·Best Practice & Research. Clinical Gastroenterology·Andre BoonstraHarry L A Janssen
Feb 17, 2009·Lancet·Yun-Fan Liaw, Chia-Ming Chu
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian J McMahon
Jul 28, 2009·The International Journal of Biochemistry & Cell Biology·Peyman Obeidy, Alexandra F Sharland
Aug 19, 2009·Immunogenetics·Amornrat V RomphrukChanvit Leelayuwat
May 19, 2010·Expert Review of Clinical Immunology·Esin AktasGunnur Deniz

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Citations

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Jan 19, 2012·FEMS Immunology and Medical Microbiology·Joyce Altamarino IbanaDanny Joseph Schust
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