Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population

BioMed Research International
Pei YuYuzhen Li

Abstract

To clarify the association between the single nucleotide polymorphisms (SNPs) in the NLRP1 and NLRP3 and Psoriasis Vulgaris (PsV) in the Chinese Han population. We genotyped eight SNPs, four from NLRP1 (rs8079034, rs11651270, rs11657747, and rs878329) and NLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with PsV and 612 healthy controls in the Chinese Han population using an improved multiplexed ligation detection reaction (iMLDR) method. The genotype and haplotype frequencies were analyzed using a case-control study design. We identified two SNPs, rs3806265 and rs10754557, in NLRP3 that were significantly associated with PsV. The genotype distribution of the rs3806265 SNP was significantly different between cases and controls (p = 0.0451; OR = 0.791; 95% CI = 0.627-0.998). In the recessive model, the genotype distribution of the rs10754557 SNP was significantly different between cases and controls (p = 0.0344; OR = 1.277; 95% CI = 0.987-1.652). The haplotype analysis of rs3806265 and rs10754557 also presented a significant association of TA haplotype with PsV (χ2 = 4.529; p = 0.033). NLRP3 may play a role in PsV susceptibility in the Chinese Han population.

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Citations

Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bing-You YangHai-Xue Kuang
Aug 10, 2019·Journal of Diabetes Research·Xiaoxiao SunZhiguang Zhou
May 1, 2021·International Journal of Molecular Sciences·Judit Danis, Mark Mellett
Jun 3, 2021·International Journal of Molecular Sciences·Magdalena CiążyńskaAleksandra Lesiak

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Methods Mentioned

BETA
biopsy
genotyping
PCR

Software Mentioned

Haploview
SPSS
HaploReg
GeneMapper

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