Association of NLRP3 single nucleotide polymorphisms with ulcerative colitis: A case-control study

Clinics and Research in Hepatology and Gastroenterology
S HanaeiNima Rezaei

Abstract

Ulcerative colitis (UC) is inflammatory bowel disease (IBD), characterized by chronic inflammation episodes within mucosal layer of the intestine mostly affecting colon and rectum. As the role of innate immunity in pathogenesis of disease and important role of NLRP3, the aim of this study is to investigate the association of NLRP3 SNPs with UC in Iranian patients. Blood samples from 45 UC patients and 56 healthy subjects were tested for single nucleotide polymorphisms in rs10754558, rs3806265, rs4612666, and rs35829419 of NLRP3 gene, using real-time PCR method. Among the investigated SNPs, "GG" genotype of rs10754558 have been 2.48 times more common among UC patients (P=0.04), while "CG" genotype has indicated protective effect against UC, as more frequently found in healthy subjects. Despite no significant association between three investigated SNPs and disease, "GG" and "CG" genotypes of rs10754558 have been significantly associated with disease.

Citations

Mar 16, 2019·Frontiers in Immunology·Yu Zhen, Hu Zhang
Apr 27, 2019·Frontiers in Immunology·Renata CurciarelloCecilia Isabel Muglia
Nov 5, 2020·International Journal of Molecular Sciences·Kohei Wagatsuma, Hiroshi Nakase
Mar 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiu-Ling ChenYing Wang
Mar 29, 2021·Cytokine & Growth Factor Reviews·Yijie SongNing Zhang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiuyun XuLiming Mao
Sep 1, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chuang WuWei Yang
Oct 28, 2021·EMBO Molecular Medicine·Daisuke WatanabeNobuhiko Kamada
Dec 10, 2021·Aging and Disease·Yu LiWeidong Le

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