Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis.

Arthritis and Rheumatism
Hermine I BrunnerPrasad Devarajan

Abstract

To investigate the relationship of urinary biomarkers and established measures of renal function to histologic findings in lupus nephritis (LN), and to test whether certain combinations of the above-mentioned laboratory measures are diagnostic for specific histologic features of LN. Urine samples from 76 patients were collected within 2 months of kidney biopsy and assayed for the urinary biomarkers lipocalin-like prostaglandin D synthase (L-PGDS), α(1) -acid glycoprotein (AAG), transferrin (TF), ceruloplasmin (CP), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemotactic protein 1 (MCP-1). Using nonparametric analyses, levels of urinary biomarkers and established markers of renal function were compared with histologic features seen in LN, i.e., mesangial expansion, capillary proliferation, crescent formation, necrosis, wire loops, fibrosis, tubular atrophy, and epimembranous deposits. The area under the receiver operating characteristic curve (AUC) was calculated to predict LN activity, chronicity, or membranous LN. There was a differential increase in levels of urinary biomarkers that formed a pattern reflective of specific histologic features seen in active LN. The combination of MCP-1, AAG, and CP levels p...Continue Reading

References

Jan 14, 2004·Kidney International·Jan J WeeningUNKNOWN Renal Pathology Society Working Group on the Classification of Lupus Nephritis
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Jan J WeeningMichio Nagata
Mar 17, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael ZappitelliIndra R Gupta
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Jaya MishraPrasad Devarajan
Dec 17, 2004·Journal of the American Society of Nephrology : JASN·Brad H RovinHaikady N Nagaraja
Dec 31, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Momoko OgawaYoshio Uehara
Nov 16, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen D MarksKjell Tullus
Nov 30, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Byong Sop LeeYong Choi
Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Deliang ZhangTracey A Rouault
Oct 25, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael ZappitelliIndra R Gupta
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Brad H Rovin
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianfu WuChandra Mohan
Jan 19, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michiko SuzukiHermine I Brunner
Jan 29, 2008·Seminars in Nephrology·Ivan C MouraRenato C Monteiro
Mar 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Michael BennettPrasad Devarajan
Jan 30, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Davide BolignanoMichele Buemi
Feb 17, 2009·Pediatric Research·Michiko SuzukiHermine I Brunner
Mar 27, 2009·Nature Reviews. Nephrology·Chi Chiu Mok
Apr 28, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Prayong VachvanichsanongEdward McNeil
Jan 13, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianfu WuChandra Mohan
Oct 6, 2010·The Journal of Clinical Investigation·Amandine ViauFabiola Terzi

❮ Previous
Next ❯

Citations

May 17, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Louise Watson, Michael W Beresford
Jan 29, 2013·Current Rheumatology Reports·Elisabeth Binder, Monika Edelbauer
Nov 14, 2012·Nature Reviews. Nephrology·Ben SprangersGerald B Appel
Jul 10, 2013·Current Opinion in Rheumatology·Julie BarsalouEarl D Silverman
Nov 19, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Louise WatsonMichael W Beresford
Apr 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·María Teresa Torres-SalidoJosep Ordi-Ros
Dec 17, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Vanessa AbellaOreste Gualillo
Nov 15, 2014·Lupus Science & Medicine·B R LauwerysF A Houssiau
Jul 19, 2016·Progress in Pediatric Cardiology·Prasad Devarajan, John Lynn Jefferies
Jan 15, 2016·Pediatric Rheumatology Online Journal·Khalid M AbulabanHermine I Brunner
Sep 25, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tomoki KosugiKenji Kadomatsu
Apr 18, 2015·International Journal of Rheumatic Diseases·Ramnath Misra, Ranjan Gupta
Mar 1, 2014·Journal of Clinical Laboratory Analysis·Moataz Fatthy MohammedSamah Abd El-Hamid
Nov 18, 2015·Seminars in Nephrology·Samir V ParikhBrad H Rovin
Sep 18, 2015·Immunologic Research·Anne DavidsonMatthias Kretzler
Jul 19, 2014·Rheumatic Diseases Clinics of North America·Brad H RovinAnthony Alvarado
May 23, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre Ronco
May 23, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·An S De Vriese, Fernando C Fervenza
Dec 17, 2014·Nature Reviews. Rheumatology·Alessandro ConsolaroAngelo Ravelli
Jan 18, 2015·Revista brasileira de reumatologia·Evandro Mendes KlumbFrancinne Machado Ribeiro
Jan 18, 2015·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Hani SusiantiHandono Kalim
Dec 6, 2014·Current Rheumatology Reports·Khalid M Abulaban, Hermine I Brunner
Jun 1, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nobuhide EndoShoichi Maruyama
Dec 20, 2015·Proteomics. Clinical Applications·Taylor E HinchliffeTianfu Wu
Jul 13, 2016·Mediators of Inflammation·Xiaofeng LiaoXin M Luo
Oct 17, 2015·Arthritis Care & Research·Hermine I BrunnerPrasad Devarajan
Jul 5, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eve M D Smith, Michael W Beresford
Jul 6, 2016·Kidney International·Hans-Joachim Anders, Brad Rovin
Aug 19, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Celine C BerthierAnne Davidson
Sep 4, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eve Mary Dorothy SmithMichael William Beresford
Sep 25, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Frank Ward, Joanne M Bargman
Aug 2, 2013·Therapeutic Advances in Musculoskeletal Disease·Chau-Ching LiuJoseph M Ahearn
Mar 8, 2016·Journal of Biomolecular Screening·Giorgio Gentile, Giuseppe Remuzzi
Sep 7, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Diego A González-SánchezJosé A Gómez-Puerta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Louise Watson, Michael W Beresford
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Stephen D MarksNeil J Sebire
Clinical Journal of the American Society of Nephrology : CJASN
Michael R BennettPrasad Devarajan
Nature Medicine
Stuart J Shankland, Martin R Pollak
© 2022 Meta ULC. All rights reserved