Association of norepinephrine transporter (NET, SLC6A2) genotype with ADHD-related phenotypes: findings of a longitudinal study from birth to adolescence

Psychiatry Research
Sarah HohmannM Laucht

Abstract

Variation in the gene encoding for the norepinephrine transporter (NET, SLC6A2) has repeatedly been linked with ADHD, although there is some inconsistency regarding the association with specific genes. The variants for which most consistent association has been found are the NET variants rs3785157 and rs28386840. Here, we tested for their association with ADHD diagnosis and ADHD-related phenotypes during development in a longitudinal German community sample. Children were followed from age 4 to age 15, using diagnostic interviews to assess ADHD. Between the ages of 8 and 15 years, the Child Behavior Checklist (CBCL) was administered to the primary caregivers. The continuous performance task (CPT) was performed at age 15. Controlling for possible confounders, we found that homozygous carriers of the major A allele of the functional promoter variant rs28386840 displayed a higher rate of ADHD lifetime diagnosis. Moreover, homozygous carriers of the minor T allele of rs3785157 were more likely to develop ADHD and showed higher scores on the CBCL externalizing behavior scales. Additionally, we found that individuals heterozygous for rs3785157 made fewer omission errors in the CPT than homozygotes. This is the first longitudinal stud...Continue Reading

References

Jan 1, 1990·European Archives of Psychiatry and Neurological Sciences·G EsserH Weinel
Oct 24, 1995·Biochemical and Biophysical Research Communications·P PörzgenM Brüss
Nov 18, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·M LauchtM H Schmidt
Oct 17, 1998·Molecular Psychiatry·P Seeman, B K Madras
Sep 25, 1999·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·H Stanislaw, N Todorov
Nov 24, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·L BavingM H Schmidt
Jan 19, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·P J Ambrosini
Sep 26, 2000·Molecular Genetics and Metabolism·D E Comings, J P MacMurray
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Mar 29, 2002·American Journal of Medical Genetics·Cathy L BarrJames L Kennedy
Aug 3, 2002·Nature Reviews. Neuroscience·F Xavier Castellanos, Rosemary Tannock
Aug 7, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Daniel BrandeisPeter Scheuerpflug
Nov 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Frank P BymasterKenneth W Perry
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Venkata S MattayDaniel R Weinberger
Jul 23, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Sandra K LooMartin L Reite
Jan 14, 2004·Psychological Bulletin·Kent E HutchisonAngela Bryan
Apr 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Iris ManorRichard P Ebstein
Feb 18, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aaron J BobbJudith L Rapoport
Feb 19, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xiaohui XuPhilip Asherson
Apr 12, 2005·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Jun 14, 2005·Biological Psychiatry·Stephen V FaraonePamela Sklar
Jun 14, 2005·Biological Psychiatry·Steven R Pliszka
Sep 22, 2006·Nature Reviews. Neuroscience·Andreas Meyer-Lindenberg, Daniel R Weinberger
Oct 27, 2006·Neurobiology of Disease·Kristy J BrunoEllen J Hess
Dec 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chun-Hyung KimKwang-Soo Kim
Feb 6, 2007·Journal of Neuroscience Methods·Vivienne Ann Russell
Nov 13, 2007·Journal of Neural Transmission·R M KostrzewaR Brus
Jan 18, 2008·Journal of Neural Transmission·O AlbayrakJ Hebebrand
Jun 5, 2008·Journal of Pediatric Psychology·Deeann WallisMaximilian Muenke
Jul 2, 2008·Annals of the New York Academy of Sciences·Chun-Hyung KimKwang-Soo Kim
Sep 30, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jessica Lasky-SuStephen V Faraone
Sep 30, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·S H KollinsA E Ashley-Koch
Nov 19, 2008·Journal of Abnormal Child Psychology·Catherine TuvbladLaura A Baker
Feb 11, 2010·European Child & Adolescent Psychiatry·Tobias BanaschewskiDavid Coghill
Feb 18, 2010·The Psychiatric Clinics of North America·Stephen V Faraone, Eric Mick
Apr 23, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Edmund Sonuga-BarkeMargaret Thompson

❮ Previous
Next ❯

Citations

Jan 21, 2016·Trends in Neurosciences·Tobias U HauserRaymond J Dolan
Apr 26, 2017·Children·Anne Herbert, Anna Esparham
Feb 6, 2017·Neuroscience and Biobehavioral Reviews·Marieke KleinBarbara Franke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.