Association of Normal Systolic Blood Pressure Level With Cardiovascular Disease in the Absence of Risk Factors

JAMA Cardiology
Seamus P WheltonMichael J Blaha

Abstract

The risk of atherosclerotic cardiovascular disease (ASCVD) at currently defined normal systolic blood pressure (SBP) levels in persons without ASCVD risk factors based on current definitions is not well defined. To examine the association of SBP levels with coronary artery calcium and ASCVD in persons without hypertension or other traditional ASCVD risk factors based on current definitions. A cohort of 1457 participants free of ASCVD from the Multi-Ethnic Study of Atherosclerosis who were without dyslipidemia (low-density lipoprotein cholesterol level ≥160 mg/dL or high-density lipoprotein cholesterol level <40 mg/dL), diabetes (fasting glucose level ≥126 mg/dL), treatment for hyperlipidemia or diabetes, or current tobacco use, and had an SBP level between 90 and 129 mm Hg. Participants receiving hypertension medication were excluded. Coronary artery calcium was classified as absent or present and adjusted hazard ratios (aHRs) were calculated for incident ASCVD. The study was conducted from March 27, 2018, to February 12, 2020. Systolic blood pressure. Presence or absence of coronary artery calcium and incident ASCVD events. Of the 1457 participants, 894 were women (61.4%); mean (SD) age was 58.1 (9.8) years and mean (SD) follo...Continue Reading

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Citations

Jan 4, 2021·European Heart Journal·Ramon EstruchFrancesco Cosentino
Feb 2, 2021·International Journal of Bipolar Disorders·Niall M McGowanKate E A Saunders

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