Association of objectively measured physical activity with brain structure: UK Biobank study

Journal of Internal Medicine
Mark HamerG D Batty

Abstract

Physical activity may be beneficial for cognition but mechanisms are unclear. We examined the association between objectively assessed physical activity and brain volume, with a focus on the hippocampus region. We used data from UK Biobank (n = 5272; aged 55.4 ± 7.5 years; 45.6% men) collected through 2013-2016. Participants wore the Axivity AX3 wrist-worn triaxial accelerometer for 7 days to assess habitual physical activity. Structural magnetic resonance imaging was performed using a standard Siemens Skyra 3T running VD13A SP4 to obtain images of the brain. There was an association between physical activity (per SD increase) and grey matter volume after adjustment for a range of covariates, although this association was only detected in older adults (>60 years old). We also observed associations of physical activity with both left (B = 0.52, 95% CI, 0.01, 1.03; P = 0.046) and right hippocampal volume (B = 0.59, 95% CI, 0.08, 1.10; P = 0.024) in covariate-adjusted models. In summary, physical activity may play a role in the prevention of neurodegenerative diseases.

References

Feb 15, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stanley J ColcombeArthur F Kramer
Jul 17, 2008·Psychophysiology·Brian A GordonMonica Fabiani
Dec 9, 2008·Neurobiology of Aging·Suvi RovioMiia Kivipelto
Jun 16, 2010·Annals of Internal Medicine·Brenda L PlassmanSophiya Benjamin
Sep 14, 2010·Journal of Internal Medicine·F SofiC Macchi
May 18, 2012·Neurobiology of Aging·Christian BenedictHelgi B Schiöth
Feb 7, 2015·Behavioural Brain Research·Qu TianUNKNOWN Health ABC Study
Oct 28, 2016·Nature Neuroscience·Karla L MillerStephen M Smith
Jun 24, 2017·BMJ : British Medical Journal·Séverine SabiaArchana Singh-Manoux

❮ Previous
Next ❯

Citations

Sep 26, 2020·Frontiers in Human Neuroscience·Frida BergmanCarl-Johan Boraxbekk
May 10, 2020·Annals of Human Biology·Ahmed EhakeemDeborah A Lawlor
Nov 25, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Amal A WanigatungaJennifer A Schrack
Feb 7, 2021·BMC Geriatrics·Noah D KoblinskyNicole D Anderson
Mar 10, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Fateme Zabetian-TarghiMichele L Callisaya
Jun 9, 2021·Hippocampus·Sarah L AghjayanKirk I Erickson
Sep 11, 2021·Neuroscience and Biobehavioral Reviews·Kelsey R SewellBelinda M Brown
Oct 20, 2021·PLoS Computational Biology·Grégory HammadChristina Schmidt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.