Association of older paternal age with earlier onset among co-affected schizophrenia sib-pairs

Psychological Medicine
S H WangW J Chen

Abstract

Background. Advanced paternal age is associated with increased risk of schizophrenia. This study aimed to explore whether older paternal age is associated with earlier onset among co-affected schizophrenia sib-pairs with the same familial predisposition. Method. A total of 1297 patients with schizophrenia from 630 families, which were ascertained to have at least two siblings affected, throughout Taiwan were interviewed using the Diagnostic Interview for Genetic Studies. Both inter-family comparisons, a hierarchical regression model allowing for familial dependence and adjusting for confounders, and within-family comparisons, examining the consistency between onset order and birth order, were performed. Results. An inverted U shape was observed between paternal age and onset of schizophrenia. Affected offspring with paternal age of 20-24 years had the oldest onset. As paternal age increased over 25 years, older paternal age exhibited a linear decrease in the onset of schizophrenia. On average, the onset was lowered by 1.5 years for paternal age of 25-29 years and by 5.5 years for paternal age ⩾50 years (p = 0.04; trend test). The proportion of younger siblings with earlier onset (58%) was larger than that of older siblings with...Continue Reading

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Citations

Oct 27, 2017·International Journal of Psychiatry in Clinical Practice·Konstantinos N FountoulakisSiegfried Kasper
Mar 19, 2019·International Journal of Psychiatry in Clinical Practice·Konstantinos N FountoulakisSiegfried Kasper
Oct 2, 2019·Cold Spring Harbor Perspectives in Medicine·Holly Landrum Peay
Nov 30, 2021·European Archives of Psychiatry and Clinical Neuroscience·Konstantinos N FountoulakisIoannis Nimatoudis

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