Association of Omnivorous and Vegetarian Diets With Antioxidant Defense Mechanisms in Men.

Journal of the American Heart Association
Naiara CinegagliaValeria Sandrim

Abstract

Background Evidence that a vegetarian diet rich in antioxidants contributes to cardiovascular health are growing, however, the underlying molecular mechanisms remain unknown. HO-1 (heme-oxygenase-1), a marker of adaptive response, is protective against oxidative stress and has shown cardioprotective effects. Therefore, we evaluated circulating HO-1 levels and the effect of plasma from omnivorous and vegetarians in endothelial cells (human umbilical vein endothelial cells) on modulating NRF2 (nuclear factor erythroid 2-like 2)/HO-1 and nitric oxide production. Methods and Results From 745 participants initially recruited, 44 omnivorous and 44 vegetarian men matched by age and absence of cardiovascular risk factors and diseases were included in this study. Circulating HO-1 was measured using ELISA and human umbilical vein endothelial cells were incubated with plasma from omnivorous and vegetarians. Higher circulating HO-1 concentrations were found in omnivorous compared with vegetarians. Plasma from omnivorous and not from vegetarians induced NRF2/HO-1 and nitric oxide production in human umbilical vein endothelial cells, and increased reactive oxygen species production and caspase activity after incubation with stressor stimulus...Continue Reading

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Citations

Sep 26, 2020·Journal of Psychosomatic Obstetrics and Gynaecology·Edna M Sant'AnnaFernando M Reis
Oct 13, 2021·Critical Reviews in Food Science and Nutrition·Goran GajskiVanessa Moraes de Andrade

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Methods Mentioned

BETA
ELISA
PCR
Assay

Software Mentioned

Stata
GeneGlobe Data Analysis Center
GraphPad Prism

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