Association of Optic Radiation Integrity with Cortical Thickness in Children with Anisometropic Amblyopia

Neuroscience Bulletin
Shun QiHong Yin

Abstract

Previous studies have indicated regional abnormalities of both gray and white matter in amblyopia. However, alterations of cortical thickness associated with changes in white matter integrity have rarely been reported. In this study, structural magnetic resonance imaging and diffusion tensor imaging (DTI) data were obtained from 15 children with anisometropic amblyopia and 15 age- and gender-matched children with normal sight. Combining DTI and surface-based morphometry, we examined a potential linkage between disrupted white matter integrity and altered cortical thickness. The fractional anisotropy (FA) values in the optic radiations (ORs) of children with anisometropic amblyopia were lower than in controls (P < 0.05). The cortical thickness in amblyopic children was lower than controls in the following subregions: lingual cortex, lateral occipitotemporal gyrus, cuneus, occipital lobe, inferior parietal lobe, and temporal lobe (P < 0.05, corrected), but was higher in the calcarine gyrus (P < 0.05, corrected). Node-by-node correlation analysis of changes in cortical thickness revealed a significant association between a lower FA value in the OR and diminished cortical thickness in the following subregions: medial lingual cortex...Continue Reading

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Citations

Aug 25, 2016·Journal of Ophthalmology·Scott C KolbeTrevor J Kilpatrick
Mar 12, 2019·Journal of Magnetic Resonance Imaging : JMRI·Lu LuXiaoqi Huang
Dec 22, 2016·Current Opinion in Neurology·Vijay K TailorAnnegret H Dahlmann-Noor
Oct 21, 2018·Journal of the Association for Research in Otolaryngology : JARO·Margo McKenna BenoitPaul Allen
Oct 4, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jeffrey R SimsKevin C Chan
Nov 19, 2020·Journal of Binocular Vision and Ocular Motility·Nathaniel P MillerBas Rokers

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