Association of oral spirochetes from sites of periodontal health with development of periodontitis

Journal of Periodontology
G R RiviereN R Hawkins

Abstract

The purpose of this investigation was to determine whether the presence of disease-associated bacteria in health-associated plaque correlated with susceptibility to periodontitis over time. Sites of periodontal health were identified in 65 adults. Six months later (recall 1), plaque was collected from sites that remained in periodontal health, and specific bacteria were detected using monoclonal antibodies in a microscopic assay. The spirochete morphogroup was identified by phase contrast microscopy. The relationship between detection at recall 1 and development of periodontitis over two successive 6-month intervals (recalls 2 and 3) was evaluated by means of logistic regression using generalized estimating equations (GEE), from which odds ratios (OR) were estimated and tested for significance. Significant relationships were defined as those having ORs with P < 0.05. Ninety-three of 1,032 sites developed signs of early periodontitis over the 12-month interval between recall 1 and recall 3. The spirochete morphogroup (OR = 3.13, P < 0.001) and pathogen-related oral spirochetes (PROS) (OR = 3.68, P < 0.001) were significantly associated with healthy sites that developed periodontitis. The association of Treponema socranskii was n...Continue Reading

References

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Citations

Jan 12, 2001·Oral Microbiology and Immunology·F E DewhirstB J Paster
Dec 12, 2001·Journal of Clinical Periodontology·P S Langendijk-GenevauxJ S van der Hoeven
Aug 17, 1999·Microbiology and Immunology·M SakamotoT Nakase
Oct 5, 2001·Clinical Microbiology Reviews·W J Loesche, N S Grossman
Jun 15, 2007·Infectious Disease Clinics of North America·Mark W Hull, Anthony W Chow
Jan 22, 2013·European Journal of Oral Sciences·Philippe HujoelRodrigo López
Aug 18, 2010·Periodontology 2000·Kazuyuki Ishihara
Jun 3, 1998·Journal of Periodontology·G R Riviere, T A DeRouen
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M N Sela
Apr 24, 2003·Journal of Dental Research·P S KumarE J Leys
Apr 28, 2005·Periodontology 2000·Richard P Ellen, Vaia B Galimanas
Jan 13, 2001·Periodontology 2000·B L Pihlstrom

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