Association of overweight and obesity with patient mortality after acute myocardial infarction: a meta-analysis of prospective studies

International Journal of Obesity : Journal of the International Association for the Study of Obesity
L WangP Yin

Abstract

The obesity paradox, which suggests that overweight and obesity exert protective effects on patient survival after acute myocardial infarction (AMI), is controversial in the existing researches. The aim of our study was to evaluate the associations of overweight and obesity with all-cause mortality in patients after AMI. The PubMed and Embase databases were searched for original articles published in English prior to March 2015, using the terms ('myocardial infarction' and ('body mass index' or BMI)) and ('mortality' or 'death'). Prospective studies that reported the relationship between overweight and obesity at baseline (immediately after AMI) and all-cause mortality outcomes were eligible. Two authors separately performed the extraction of the data, and any differences were discussed and resolved. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were computed either by fixed effects or random effects models. Twenty studies were included in the present analysis. Comparing a healthy weight group to a combined overweight and obese group, the pooled RRs were 0.72 (95% CI: 0.57-0.90) for in-hospital mortality, 0.39 (95% CI: 0.28-0.55) for short-term mortality, 0.66 (95% CI: 0.55-0.78) for medium-term mortality and 0...Continue Reading

References

Aug 2, 2002·The New England Journal of Medicine·Satish KenchaiahRamachandran S Vasan
Oct 3, 2003·The American Journal of Clinical Nutrition·Pasquale AbeteFranco Rengo
May 8, 2004·American Heart Journal·Jamal S RanaMurray A Mittleman
Jan 5, 2005·Journal of the American College of Cardiology·Linn M A KennedyUNKNOWN OPTIMAAL Study Group
Jan 29, 2005·International Journal of Cardiology·Charlotte KragelundUNKNOWN TRACE study group
Dec 22, 2005·American Heart Journal·Eugenia NikolskyRoxana Mehran
Aug 9, 2006·The American Journal of Cardiology·Bryan WellsCarolyn K Landolfo
Mar 28, 2007·American Journal of Hypertension·Rebecca P GelberHoward D Sesso
Jun 20, 2007·European Heart Journal·Heinz J BuettnerFranz-Josef Neumann
Oct 17, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Harm WienbergenUNKNOWN MITRA PLUS study group
Feb 22, 2008·The American Journal of Cardiology·Abelardo Martinez-RumayorJames L Januzzi
Mar 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masami KosugeUNKNOWN Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Jul 16, 2008·Circulation·Marianne ZellerUNKNOWN RICO Survey Working Group
Jan 26, 2010·International Journal of Cardiology·Doron AronsonZaher S Azzam
Feb 16, 2010·The American Journal of Cardiology·Gabriel GreenbergEli I Lev
Apr 10, 2012·The American Journal of Medicine·Emily M BucholzHarlan M Krumholz
Aug 21, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C LazzeriG F Gensini
Oct 23, 2012·International Journal of Cardiology·Patricia IozzoClara Carpeggiani
Jan 21, 2014·Progress in Cardiovascular Diseases·Jongha ParkKamyar Kalantar-Zadeh
Feb 11, 2015·The Canadian Journal of Cardiology·Pritha P GuptaTamara B Horwich
Feb 12, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Raquel BarbaAntonio Zapatero-Gaviria

❮ Previous
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Citations

Jul 14, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A S AntonopoulosD Tousoulis
May 27, 2017·Cardiovascular Research·Alexios S Antonopoulos, Dimitris Tousoulis
Oct 14, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Peeters
Feb 23, 2018·The Journal of International Medical Research·Mohamad JarrahIssa M Hweidi
Sep 30, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D Kilov, G Kilov
Feb 20, 2018·Journal of the American Heart Association·Yejin MokKunihiro Matsushita
Sep 17, 2018·European Heart Journal. Quality of Care & Clinical Outcomes·Sebastian Johannes ReinstadlerBernhard Metzler
Mar 14, 2020·Current Cardiology Reports·Alok Kumar DwivediSireesha Y Reddy
May 28, 2020·Frontiers in Nutrition·Lorenzo Maria DoniniEleonora Poggiogalle
Aug 28, 2020·Eating and Weight Disorders : EWD·Maria Pia DonataccioOttavio Bosello
Nov 22, 2017·Clinical Chemistry·John M JakicicKatherine A Collins
Aug 19, 2018·BMC Surgery·Lubomír TulinskýPeter Ihnát
Apr 25, 2020·JACC. Cardiovascular Interventions·Sebastian Johannes Reinstadler, Bernhard Metzler
Dec 2, 2020·Diabetes & Metabolism·Volker H SchmittKarsten Keller
Mar 9, 2021·Journal of Family Medicine and Primary Care·Varvara-Maria ChaliotiDespina N Perrea
May 1, 2021·Journal of Clinical Medicine·José M de Miguel-YanesAna Lopez-de-Andres

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