Abstract
This paper evaluates the association of oxidative stress and atherogenic index of plasma in order to assess the cardiovascular risk in Sickle cell nephropathy especially as lipoprotein levels are lower in SCD than non-SCD patients. Antioxidant enzymes, malondialdehyde(MDA), urea, creatinine, and glomerular filtration rate were evaluated in 110 confirmed sickle cell disease patients: 65 males in steady state, aged 21.1 ± 6.0 years, 30 males with macroalbuminuria, aged 24.5 ± 7.0, years and 15 with chronic kidney disease (CKD), aged 31.8 ± 2.0 years. The mean activity levels of glutathione peroxidase (GPx), superoxide dismutase (Cu/ZnSOD), and catalase (CAT) were significantly lower (P < 0.001) in SCD with macroalbuminuria and CKD while MDA was higher (P < 0.001) in SCD with macroalbuminuria and CKD compared with controls. There was negative correlation between GPx (P < 0.001), Cu/ZnSOD (P < 0.02), and Atherogenic index of plasma in SCD with CKD, while MDA shows a positive correlation (P < 0.001) with AIP in SCD with CKD. There was however no correlation between CAT and AIP. Decreased activity levels of antioxidant enzymes and low HDL-cholesterol concentration were confirmed in adult SCD with CKD in Nigerians. The increase oxidat...Continue Reading
References
Feb 1, 1978·Pediatric Research·J YamR J Roberts
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jan 1, 1976·Vision Research·J C Armington
Dec 1, 1992·Current Opinion in Nephrology and Hypertension·H T Morehouse
Oct 1, 1992·Postgraduate Medical Journal·C R Tomson
Jan 1, 1986·Annual Review of Physiology·I Fridovich, B Freeman
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·R E Ratych, G B Bulkley
Sep 1, 1986·Pediatric Neurology·D ZochodneE Ecclestone
Dec 1, 1982·The Journal of Clinical Investigation·R P HebbelM H Steinberg
Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
Dec 29, 2000·Journal of Pediatric Hematology/oncology·C R MorrisL A Styles
Nov 1, 2001·Respiratory Research·E S Klings, H W Farber
Apr 10, 2003·American Journal of Physiology. Renal Physiology·Timothy A SuttonBruce A Molitoris
Aug 28, 2003·Nature Immunology
Jun 11, 2005·BioTechniques·Tai-Chih Kuo
Jun 21, 2005·Clinical Biochemistry·Krystyna PawlakMichal Mysliwiec
Sep 28, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zohreh RahimiRonald L Nagel
Mar 15, 2006·Trends in Pharmacological Sciences·Martin H Steinberg
Feb 12, 2008·Free Radical Biology & Medicine·Katherine C WoodMark T Gladwin
Mar 21, 2008·Journal of Neurosurgery. Pediatrics·Jack R Engsberg, Tae Sung Park
Aug 23, 2008·Journal of the National Medical Association·Vanusa ManfrediniMara Silveira Benfato
Mar 17, 2009·Annals of the Rheumatic Diseases·E Choy, N Sattar
Jan 26, 2010·Antioxidants & Redox Signaling·Ines Batinić-HaberleIvan Spasojević
Mar 17, 2010·British Journal of Haematology·Suzana ZorcaGregory J Kato
Aug 17, 2010·Annals of African Medicine·M A EmokpaeA A Gadzama
Feb 12, 2011·Annals of African Medicine·A AbduA Kuliya-Gwarzo
Jan 3, 2012·Indian Journal of Clinical Biochemistry : IJCB·M A EmokpaeH B Osadolor
Citations
Jun 14, 2013·Food & Function·Aparajita Dey, J Lakshmanan
Nov 20, 2016·BMC Nephrology·Karen E ItokuaNazaire M Nseka
Aug 9, 2019·Biomarkers in Medicine·André R BelisárioAna C Simoes-E-Silva
Jul 29, 2016·Medical Sciences : Open Access Journal·Mathias Abiodun EmokpaeEvarista Osime
Sep 18, 2020·Antioxidants·Fatou Gueye TallPhilippe Joly
Apr 8, 2020·Advances in Hematology·Landry Nguepnkep KubongConstant Anatole Pieme