Association of p53 arginine polymorphism with skin cancer

International Journal of Dermatology
Walmar Roncalli P de OliveiraStephen K Tyring

Abstract

The presence of arginine at codon 72 in p53 protein is proposed to be a genetic risk factor in human papillomavirus (HPV)-related carcinogenesis. To study the prevalence of p53 polymorphism at codon 72 in skin biopsies of epidermodysplasia verruciformis (EV) patients compared to DNA samples from healthy individuals. DNA samples extracted from normal skin and tumor biopsies of 22 Brazilian patients with EV and blood samples from 27 healthy Brazilian individuals were studied for p53 codon 72 polymorphisms using restriction fragment length polymorphism (RFLP) analysis. All EV patients with the malignant form of EV were homozygous for arginine (Arg/Arg) at codon 72 of the p53 gene, in contrast to none with the benign form (P < 0.0001). p53 arginine polymorphism is likely to be associated with the development of skin malignancies in EV patients from Brazil.

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Apr 15, 2003·The Journal of Dermatology·Walmar Roncalli Pereira de OliveiraStephen K Tyring
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Citations

Jan 18, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Arshad A PandithMushtaq A Siddiqi
Mar 22, 2006·Oncogene·E C PietschM E Murphy
Nov 22, 2008·Journal of the American Academy of Dermatology·Caroline Le PooleJack L Arbiser
Sep 24, 2010·The Journal of Investigative Dermatology·De-Ke JiangLong Yu
Oct 24, 2007·Cancer Genetics and Cytogenetics·Boutheina Hadhri-GuigaRaja Mokdad-Gargouri
Feb 14, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y ShaoS Zhang
Nov 19, 2009·Journal of Cutaneous Medicine and Surgery·Walmar R OliveiraStephen K Tyring
Jul 15, 2015·Journal of Cutaneous Medicine and Surgery·Walmar Roncalli de OliveiraStephen Tyring

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