Association of p53 protein expression with responses and survival of patients with locally advanced esophageal carcinoma treated with chemoradiotherapy

Japanese Journal of Clinical Oncology
K MuroT Hasebe

Abstract

Immunohistochemical analysis was performed to determine the clinical role of p53 mutations in patients with locally advanced esophageal carcinomas treated with concurrent chemoradiotherapy. The subjects of this study were 20 patients with previously untreated esophageal carcinomas with evidence of T4 disease and/or distant node metastases. Treatment comprised protracted 5-fluorouracil and 2-h cisplatinum infusions along with radiation treatment with a total radiation dose of 60 Gy. Tumor specimens from 18 of the 20 patients were analyzed immunohistochemically. Mutant p53 protein expression in the biopsy materials from the primary tumors was analyzed by immunohistochemical staining using a polyclonal antibody, RSP53. Expression of p53 was detected immunohistochemically in 10 (56%) of the 18 esophageal tumors, the cancer cell nuclei of which were diffusely stained. There were no significant differences between the patient backgrounds of the p53-"positive" and "negative" groups. Four (40%) of the 10 patients with p53 expression achieved overall complete remissions (CRSs) and 7 (70%) of these 10 achieved CRs of their primary tumors. In contrast, none of the 8 p53-negative patients achieved overall CRs and two (25%) achieved CRs of ...Continue Reading

Citations

Mar 16, 2006·Journal of Cancer Research and Clinical Oncology·Franziska Pühringer-OppermannMario Sarbia
Sep 24, 2002·International Journal of Radiation Oncology, Biology, Physics·Pierre MichelBernard Paillot
Jul 8, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y ShimadaM Imamura
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P SoontrapornchaiB Iacopetta
Mar 29, 2000·Critical Reviews in Oncology/hematology·A K Lam
Sep 13, 2001·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S TakenoS Yokoyama
Nov 27, 2009·Annals of Surgical Oncology·Makoto YamasakiYuichiro Doki

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