Abstract
To investigate the association of the genetic polymorphisms of the plasminogen activator inhibitor type 1 (PAI-1) gene with the risk of ischemic stroke (IS) in subjects with type 2 diabetes mellitus (T2DM). Using a case-control study design, 175 individuals with T2D and IS were enrolled in the case group and 125 patients with T2D without IS were enrolled as controls. The clinical characteristics of the groups were compared, and genotypes were determined by direct DNA sequencing. Male and hypertensive subjects were higher in the IS group (p = 0.002 and 0.014, respectively). High-density lipoprotein (HDL) and apolipoprotein A1 (APOA1) were lower in the IS group (p = 0.011 and 0.025, respectively); hemoglobin A1c (HbA1c), total homocysteine (tHcy), and FT4 levels were higher in the IS group (p = 0.022, 0.003, and 0.008, respectively). The 4G/4G, 4G/5G, and 5G/5G genotype frequencies were 40.0%, 46.4%, and 13.6% in the control group versus 31.4%, 52.0% and 16.6% in the IS group, respectively. Hypertension (odds ratio [OR] = 1.953, p = 0.020), tHcy (OR = 1.059, p = 0.029), thyroid-stimulating hormone (OR = 0.876, p = 0.039), and the PAI-1 genotype dominant allele model (OR = 1.748, p = 0.047) were associated with IS by multivariate ...Continue Reading
References
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S DawsonS Humphries
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·P ErikssonA Hamsten
Jan 7, 1997·Circulation·P M RidkerJ P Miletich
Jan 5, 2000·Circulation·M RoestD E Grobbee
Jan 29, 2000·Kidney International·T Y WongP K Li
Aug 26, 2000·Brain : a Journal of Neurology·A Hassan, H S Markus
Sep 6, 2000·British Journal of Haematology·G EndlerC Mannhalter
Feb 24, 2001·Circulation·A ElbazUNKNOWN GENIC investigators
Jun 1, 2001·Cerebrovascular Diseases·C O BangS Y Hong
Apr 26, 2002·Allergy·D BuckováJ Vácha
Sep 10, 2003·The Journal of Laboratory and Clinical Medicine·Chih-Hung ChenTsun-Mei Lin
Nov 5, 2003·Journal of Hypertension·Judith A Whitworth, UNKNOWN World Health Organization, International Society of Hypertension Writing Group
Nov 25, 2003·Stroke; a Journal of Cerebral Circulation·Mark Roest, Jan Dirk Banga
Apr 17, 2004·Journal of Thrombosis and Thrombolysis·Francesco BurzottaFelicita Andreotti
Nov 10, 2004·Archives of Neurology·Juan P CasasPankaj Sharma
Jul 16, 2005·Stroke; a Journal of Cerebral Circulation·Per-Gunnar WiklundKjell Asplund
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·Katarina JoodChristina Jern
Feb 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·A ArboixM Balcells
Jun 29, 2006·European Neurology·Adrià ArboixJuan Massons
Aug 22, 2006·Expert Review of Cardiovascular Therapy·L Romayne KurukulasuriyaJames Sowers
Jan 10, 2009·Stroke; a Journal of Cerebral Circulation·Xingyu WangUNKNOWN RMS Stroke SNP Consortium
Aug 8, 2009·Neurological Research·Susanna MoskauMichael Linnebank
Oct 24, 2009·Cerebrovascular Diseases·Ralph WeberUNKNOWN German Stroke Study Collaboration
Nov 26, 2009·Diabetes Care·Naoto KatakamiYoshimitsu Yamasaki
Apr 30, 2010·Arquivos brasileiros de cardiologia·Milene MoehleckeLuis Henrique Canani
Mar 5, 2011·Molecular Biology Reports·Adriano de Paula SabinoAna Paula Fernandes
Sep 9, 2011·European Heart Journal·Qibin QiLu Qi
Jan 13, 2012·Endocrine, Metabolic & Immune Disorders Drug Targets·Adviye ErgulSusan C Fagan
Apr 12, 2012·Current Diabetes Reports·Michael S PhippsWalter N Kernan
May 23, 2012·CNS Neuroscience & Therapeutics·Yi ChaiGang Hu
Oct 9, 2012·Stroke; a Journal of Cerebral Circulation·Steve BevanHugh S Markus
Feb 7, 2013·The International Journal of Neuroscience·Elif UnalFikri Ak
May 8, 2014·Cerebrovascular Diseases Extra·Christopher O LeonardsMartin Ebinger
Jun 12, 2014·Postgraduate Medicine·Jennifer B Green
Aug 15, 2014·Seminars in Thrombosis and Hemostasis·Koji YamamotoHidehiko Saito
Oct 18, 2014·European Neurology·Marwan El-KoussyMarcel Arnold
Oct 31, 2014·Stroke; a Journal of Cerebral Circulation·James F MeschiaUNKNOWN Council on Hypertension
Dec 17, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Devin L BrownLynda D Lisabeth
Dec 17, 2014·World Journal of Diabetes·Konstantinos TziomalosApostolos I Hatzitolios
Jun 4, 2015·Stroke; a Journal of Cerebral Circulation·Liyuan HanShiwei Duan
Aug 8, 2015·The Diabetes Educator·Shuzhen ZhuLinglin Kong
Aug 25, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Guang-Yu ChenJian-Gao Fan
Jan 9, 2016·Molecular Neurobiology·Xin HuChao You
Mar 19, 2016·Journal of Diabetes Research·Khalid Al-RubeaanHeba M Ibrahim