Association of parathormone and alkaline phosphatase with bone turnover and mineralization in children with CKD on dialysis: effect of age, gender, and race.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Emilia M D SoeiroRosa Maria Affonso Moysés

Abstract

Studies investigating bone histology in children with chronic kidney disease (CKD) are scarce. Forty-two patients, mean age 11.3 ± 4.3 years with stage 5 CKD on dialysis, underwent double tetracycline labeling bone biopsy and the relationship between clinical features, biochemical markers, and bone densitometry (DXA) was investigated. Low bone turnover was present in 59% of patients, abnormal mineralization in 29%, and low bone volume in 7%. Higher bone formation rate was found in non-Caucasian patients, whereas abnormal mineralization occurred in older and shorter children. We found no impact of gender and etiology of renal disease in our population. Parathormone (PTH) and alkaline phosphatase (AP) showed positive associations with bone turnover. ROC curve analysis showed a fair performance of biomarkers to predict TMV status. PTH < 2 times ULN independently associated with low bone turnover (RR 5.62, 95% CI 1.01-31.24; p = 0.049), in a model adjusted for race, calcitriol dosage, and calcium. It was also associated with abnormal mineralization (RR 1.35, 95% CI 1.04-1.75; p = 0.025), in a model adjusted for BMD scores, AP, age, and calcitriol. PTH and AP significantly predicted turnover and mineralization defect, although with ...Continue Reading

References

May 1, 1988·Kidney International·I B SaluskyW G Goodman
Jun 1, 1982·Kidney International·E M HodsonP F Shaw
Aug 1, 1980·The Journal of Pediatrics·M E NormanH Rasmussen
Mar 7, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·F YalçinkayaN Ozkaya
Jul 27, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C P Sanchez
Aug 8, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Cristina AndradeCynthia Brandão
Oct 31, 2007·Journal of Bone and Mineral Metabolism·Luciene M Dos ReisVanda Jorgetti
May 16, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Simon WallerLesley Rees
Nov 13, 2008·Nephron. Clinical Practice·Daniela Veit BarretoMaria Eugênia Fernandes Canziani
Jul 17, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Sevcan A BakkalogluIsidro B Salusky
Nov 5, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Katherine Wesseling-PerryIsidro B Salusky
Aug 3, 2012·Kidney International·Tilman B Drüeke, Patrick S Parfrey
Dec 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David W DempsterA Michael Parfitt
Dec 20, 2013·Kidney International·Vanda JorgettiSusan M Ott
Mar 25, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Catherine M GordonBabette S Zemel
Dec 11, 2014·Kidney International·Rodrigo A de OliveiraVanda Jorgetti
Feb 2, 2015·Current Osteoporosis Reports·Katherine Wesseling-Perry
Jul 4, 2015·Journal of the American Society of Nephrology : JASN·Michelle R DenburgMary B Leonard
Sep 1, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stuart M SpragueSharon M Moe
Jan 26, 2016·Kidney International·Tilman B Drüeke, Ziad A Massy
Sep 30, 2016·Journal of the American Society of Nephrology : JASN·Kathrin Eller, Alexander R Rosenkranz
Jul 1, 2017·Kidney International Supplements·UNKNOWN Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group
Jun 27, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A D LalayiannisR Shroff

❮ Previous
Next ❯

Citations

Oct 24, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alexander D LalayiannisRukshana Shroff
Mar 28, 2021·Calcified Tissue International·Ana Carina FerreiraUNKNOWN European Renal Osteodystrophy (EUROD), an initiative of the CKD-MBD working group of the ERA-EDTA

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Journal of the American Society of Nephrology : CJASN
Sevcan A BakkalogluIsidro B Salusky
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Katherine Wesseling-Perry
Clinical Journal of the American Society of Nephrology : CJASN
Susan M Ott
Journal of the American Society of Nephrology : JASN
M C Monier-FaugereHartmut H Malluche
© 2021 Meta ULC. All rights reserved