Association of Parental Environmental Exposures and Supplementation Intake with Risk of Nonsyndromic Orofacial Clefts: A Case-Control Study in Heilongjiang Province, China

Nutrients
Yanru HaoDeshu Zhuang

Abstract

The aim of present study was to check the possible association of potential parental environmental exposures and maternal supplementation intake with the risk of nonsyndromic orofacial clefting (NSOC). A retrospective study comprised 499 cases and 480 controls was conducted in Heilongjiang Province. Chi-square analysis and unconditional multiple logistic regression were used in the study. The results showed that maternal history of fever and the common cold without fever (ORCL/P = 3.11 and 5.56, 95%CI: 1.67-5.82 and 2.96-10.47, ORCPO = 3.31 and 8.23, 95%CI: 1.58-6.94 and 4.08-16.95), paternal smoking and alcohol consumption (ORCL/P = 2.15 and 5.04, 95%CI: 1.37-3.38 and 3.00-8.46, ORCPO = 1.82 and 4.40, 95%CI: 1.06-3.13 and 2.50-7.74), maternal exposure to organic solvents, heavy metals, or pesticides (ORCL/P = 6.07, 5.67 and 5.97, 95%CI: 1.49-24.76, 1.34-24.09 and 2.10-16.98, ORCPO = 10.65, 7.28 and 3.48, 95%CI: 2.54-44.67, 1.41-37.63 and 1.06-11.46) and multivitamin use during the preconception period (ORCL/P = 0.06, 95%CI: 0.02-0.23, ORCPO = 0.06, 95%CI: 0.01-0.30) were associated with cleft lip or without cleft palate (CL/P) and cleft palate only (CPO). Maternal history of skin disease and negative life events (ORCL/P = 12.0...Continue Reading

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Citations

Jun 21, 2017·International Journal of Environmental Research and Public Health·Stephanie LyJane C Figueiredo
Mar 31, 2018·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Yanfen YangLei Jin
Aug 6, 2017·Environmental Health : a Global Access Science Source·Nynke SpinderHermien E K de Walle
Feb 14, 2020·Environmental Science. Processes & Impacts·Ann AschengrauDavid M Ozonoff
Mar 15, 2020·European Journal of Oral Sciences·Hosung ShinEun Joo Choi
May 16, 2018·The Journal of Craniofacial Surgery·Arezoo JahanbinMostafa Abtahi
Oct 31, 2020·Birth Defects Research·Michael A GarlandChengji J Zhou
Sep 28, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Matthew FellSarah Lewis
Nov 18, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Congna ChaiShubin Jin

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