Association of perioperative factor XIII activity levels and other haemostatic markers with the risk of postoperative intracranial haematoma in a selected cohort of neurosurgical patients

Acta neurochirurgica
Zamzuri IdrisWan Zaidah Abdullah

Abstract

Coagulation factor XIII and other haemostatic markers are known strengthen fibrin clot formation and, hence, may facilitate safer surgery. Currently however, factor XIII activity levels are not routinely screen. Therefore, the purpose of this study was to determine the association of perioperative factor XIII activity levels and other haemostatic markers with postoperative intracranial haematoma formation in neurosurgical patients. Between January 2008 to Jun 2009, all neurosurgical patients who underwent intracranial surgery were screened for the study. Patients had blood samples taken preoperatively and within 24 h post-surgery for factor XIII and other haemostatic markers. The intracranial surgeries for the patients involved were performed according to their respective indications using standard neurosurgical techniques. Postoperatively, patients had a computed tomography (CT) brain scan, with the imaging results grouped into three classes: significant haematoma (group I), insignificant haematoma (group II) and no haematoma (group III). Of the total 84 enrolled patients, 5 (6%), 28 (33.3%) and 51 (60.7%) patients were assigned to group I, II and III respectively. Significant postoperative haematoma that required re-surgery w...Continue Reading

References

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Citations

May 30, 2014·British Journal of Anaesthesia·D AdelmannE Schaden
Sep 6, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Jennifer HannaUlf Schött
Dec 3, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Christopher BeynonOliver W Sakowitz
Aug 28, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Fernando A ChuliberMarta E Martinuzzo

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