Association of peripartum troponin I levels with left ventricular relaxation in women with hypertensive disorders of pregnancy

Open Heart
Takeshi UmazumeHisanori Minakami

Abstract

Women with hypertensive disorders of pregnancy (HDP) show elevated risk of heart failure despite decreased circulating plasma volume compared with those with normotensive control pregnancies (NCP). This study was performed to better characterise the heart in women with HDP and determine whether high-sensitivity troponin I (hs-TnI) around childbirth predicts reduced left ventricular (LV) relaxation at 1 month postpartum. Echocardiography was performed longitudinally during the first, second and third trimesters and immediately postpartum within 1 week and 1 month postpartum in 24 women with HDP, with simultaneous determination of blood variables in comparison with 51 women with NCP. Compared with NCP, HDP showed greater antepartum left atrial (LA) volume, LV mass and inferior vena cava (IVC) diameter, higher peripartum brain natriuretic peptide/N-terminal pro-B-type natriuretic peptide and hs-TnI with the highest value immediately postpartum, and lower early diastolic mitral annular velocity (e') during pregnancy/postpartum. In analyses of data on HDP and NCP, hs-TnI at the third trimester as well as that immediately postpartum was negatively correlated with later e' at 1 month postpartum. The areas under the receiver operating ...Continue Reading

References

Nov 14, 1996·The New England Journal of Medicine·H P SchobelR E Schmieder
Dec 16, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·S M FlemingJ J Morrison
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A SimmonsRichmond W Jeremy
Jul 1, 1965·Anesthesiology·J A PRITCHARD
Jan 24, 2004·Anesthesiology·Simon Gelman, Phillip S Mushlin
Jul 14, 2005·Fundamental & Clinical Pharmacology·Alphons J H M HoubenPeter W de Leeuw
Aug 3, 2005·The Journal of Clinical Investigation·Ichiro ShiojimaKenneth Walsh
Aug 16, 2005·American Journal of Obstetrics and Gynecology·Jamie L ResnikAlan Maisel
Nov 5, 2005·Trends in Endocrinology and Metabolism : TEM·Monica Forero McGrathAdolfo J de Bold
Aug 22, 2006·Lancet·Karen SliwaUri Elkayam
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Aug 28, 2009·The New England Journal of Medicine·Till KellerStefan Blankenberg
Oct 24, 2009·Journal of the American College of Cardiology·Wayne L MillerAllan S Jaffe
Jul 24, 2012·Clinical Endocrinology·Takashi YamadaHisanori Minakami
Sep 25, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M E EstensenS Aakhus
Sep 10, 2013·Journal of the American College of Cardiology·Natalie BelloZoltan Arany
Mar 10, 2016·JAMA : the Journal of the American Medical Association·Ida BehrensHeather A Boyd
Apr 3, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehAlan D Waggoner
Oct 23, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·C V AnanthJ D Wright
Jul 31, 2018·Open Heart·Takeshi UmazumeHisanori Minakami

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Citations

Dec 4, 2020·BMC Pregnancy and Childbirth·Takeshi UmazumeHisanori Minakami

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Methods Mentioned

BETA
Assay

Software Mentioned

JMP Pro
SPSS Statistics

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