Association of pernicious anemia and intrinsic factor antibody with HLA-D

Tissue Antigens
M ThomsenA Svejgaard

Abstract

One-hundred-and-six patients with pernicious anemia were HLA-A, B, C typed by serological technique and HLA-D typed by mixed lymphocyte culture technique for the specificities HLA-Dw1 - 8 and the locally defined D "H". In 13 cases, the D-typing was unsuccessful due to technical difficulties. HLA-A, B, C antigen frequencies did not show any significant deviation from expected values, while D typing showed increased frequencies of Dw2 and Dw5 and a possibly decreased frequency of Dw3. The typing was compared with clinical data such as the presence of organ specific autoimmune disease in first degree relatives, presence of anemia or myelopathy at time of diagnosis and presence of antibodies towards parietal cells or intrinsic factor. The presence of intrinsic factor antibody was associated with the presence of Dw2 and a decrease of Dw5 and possibly also with a decrease of Dw4. No associations were found for the other investigated parameters. If intrinsic factor antibodies have a pathogenetic role, our findings might reflect a heterogeneity of pernicious anemia. These findings and the recently reported association between HLA-DR5 and Hashimoto's disease link these two thyrogastric diseases together to form a special subgroup within...Continue Reading

References

Aug 19, 1965·The New England Journal of Medicine·W J IRVINE

❮ Previous
Next ❯

Citations

Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·C M Zmijewski
May 1, 1984·Allergy·K BechH Nielsen
Nov 1, 1983·Tissue Antigens·U Feldt-RasmussenM Thomsen
May 1, 1991·Journal of Gastroenterology and Hepatology·R G Strickland
Jan 1, 1983·Immunological Reviews·P StastnyG Nunez
Feb 1, 1983·Tissue Antigens·M ThomsenA Svejgaard
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.