Association of PICALM Gene Polymorphisms with Alzheimer's Disease: Evidence from an Updated Meta-Analysis

Current Alzheimer Research
Fang-Fang ZengChun-Xia Jing

Abstract

Previous studies have examined the roles of three polymorphisms (rs3851179, rs541458, and rs592297) of the PICALM gene in susceptibility to Alzheimer's disease (AD) with inconclusive findings. We performed a meta-analysis to explore whether these three polymorphisms in the PICALM gene were associated with susceptibility to AD. Bibliographical searches were conducted in the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) databases. Summary Odds Ratios (ORs) with 95% Confidence Intervals (CIs) were used to assess the strength of association in a random effects model. Potential sources of heterogeneity were identified by subgroup and meta-regression analyses. Twenty studies (9,017 cases and 15,448 controls) on rs3851179, 12 studies (8,077 cases and 12,022 controls) on rs541458, and 4 studies (2,106 cases and 2,234 controls) on rs592297 were considered eligible for meta-analyses. For both rs3851179 and rs541458, the overall ORs were significant under all genetic models with mild heterogeneity. Compared with G carriers, A carriers of rs3851179 were associated with a decreased risk of AD (OR = 0.88; 95% CI 0.84, 0.91, P for Z-test <0.001, I2 = 0.0%). Compared with T carriers, C carriers of rs541458 ...Continue Reading

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Jan 22, 2020·Current Alzheimer Research·Keshen Li
May 1, 2021·Molecular Neurodegeneration·Mabel SetoTimothy J Hohman
Jun 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Nathan M WillyEmanuele Cocucci

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