Association of plasma triglyceride-rich lipoprotein remnants with coronary atherosclerosis in cases of sudden cardiac death

Atherosclerosis
S TakeichiK Nakajima

Abstract

Among the risk factors for coronary atherosclerosis, elevated LDL-C level is best known. The action of lipoprotein lipase on triglyceride-rich lipoproteins produces remnant lipoprotein particles enriched in cholesterol and apolipoprotein E (apo E). Apo E serves as the ligand for uptake of remnant lipoproteins via the LDL-receptor or the remnant receptor. In this study, postmortem plasma total cholesterol, triglycerides (TG), VLDL-C, HDL-C, lipoprotein (a) [Lp(a)] and remnant-like lipoprotein particles (RLP)-cholesterol, RLP-TG, apolipoproteins B, C III and E were measured, together with LDL-C to assess their potential contribution to the severity of coronary and aortic atherosclerosis of the 197 cases of sudden death (132 cardiac death and 65 non-cardiac death). In all cases, the severity of coronary atherosclerosis was determined at postmortem pathological examination. RLP-cholesterol (RLP-C) and LDL-C concentrations were significantly higher in cases with advanced coronary atherosclerosis compared with those without coronary atherosclerosis; respective median values were 13.5 vs 8.4 mg/dl (P < 0.001) and 140 vs 115 mg/dl (P < 0.05). RLP-C levels were more strongly correlated with the severity score of coronary atherosclerosis...Continue Reading

References

Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·A Hamsten
Jan 1, 1986·Methods in Enzymology·I Hara, M Okazaki
Mar 1, 1986·The American Journal of Forensic Medicine and Pathology·S TakeichiM Maeiwa
Mar 1, 1985·The American Journal of Forensic Medicine and Pathology·S TakeichiI Shikata
Sep 1, 1984·The American Journal of Forensic Medicine and Pathology·S TakeichiI Shikata
Apr 15, 1995·Thrombosis Research·R KnöflerA Takada
Jun 1, 1995·Current Opinion in Lipidology·F Karpe, A Hamsten
Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K NakajimaE Campos
Jan 1, 1994·Journal of Atherosclerosis and Thrombosis·K NakajimaT Murase
Jan 1, 1994·Journal of Atherosclerosis and Thrombosis·S TomonoK Nakajima
Jan 1, 1997·International Journal of Legal Medicine·S TakeichiK Nakajima
Dec 24, 1960·British Medical Journal·J N GLANVILLE
Sep 1, 1961·Journal of Clinical Pathology·J B ENTICKNAP

❮ Previous
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Citations

Mar 10, 2001·Diabetes/metabolism Research and Reviews·G H Tomkin, D Owens
Feb 25, 2005·Current Atherosclerosis Reports·ThB TwicklerJ S Cohn
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Naoki OharaKatsuyuki Nakajima
Apr 30, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sanae TakeichiKatsuyuki Nakajima
Nov 13, 2001·The American Journal of Cardiology·E J SchaeferJ J Rubenstein
May 16, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·M OkazakiK Nakajima
Jan 30, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shinichi UsuiMitsuyo Okazaki
Nov 2, 2001·Atherosclerosis·R A AndersonJ Goodfellow
Jun 13, 2001·Journal of the American College of Cardiology·P J NestelJ Chin-Dusting
Nov 22, 2000·Current Opinion in Lipidology·R J Havel
Feb 22, 2002·Current Opinion in Nephrology and Hypertension·Surekha MathurIshwarlal Jialal
Feb 1, 2007·Neuropsychiatric Disease and Treatment·Takahiko Nagamine
Oct 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jason L JohnsonChristopher L Jackson
Sep 4, 2015·International Journal of Molecular Sciences·Tomohisa NaganoYoshio Aizawa
Nov 19, 2010·Forensic Science International : Synergy·Katsuyuki NakajimaMasaki Q Fujita
May 22, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yoshitaka SekineKazuhiro Suzuki
Jul 25, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroshi OkamotoKatsuyuki Nakajima
Feb 2, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katsuyuki NakajimaAkira Tanaka
Dec 21, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Naoki OharaHarumi Okuyama
Aug 17, 2004·American Heart Journal·Vera BittnerUNKNOWN Women's Angiographic Vitamin & Estrogen Investigators
Jun 26, 2007·Journal of Atherosclerosis and Thrombosis·Yuka NabenoMichitaka Naito
Apr 22, 2015·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jennifer Joan RyanHeather Zwickey
Dec 26, 2012·Journal of the American College of Cardiology·Anette VarboBørge G Nordestgaard
May 3, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katsuyuki NakajimaAkira Tanaka
Sep 28, 2005·Diabetes Care·Akira SatohTsutomu Imaizumi
Nov 18, 2004·Journal of Lipid Research·Axel SchlittXian-Cheng Jiang
Aug 15, 2002·Circulation·Pernette R W de Sauvage NoltingUNKNOWN Examination of Probands and Relatives in Statin Studies with Familial Hypercholesterolemia (ExPRESS) Study Group
Mar 27, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Keiji OiAkira Takeshita
Jun 11, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Claudia ImkeJ David Curb
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·D T SteinI Jialal
Dec 19, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Richard J Havel

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