Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis.

International Journal of Experimental Pathology
Ke-Min ChenHsiu-Hsiung Lee

Abstract

Blood-central nervous system (blood-CNS) barrier breakdown, an important pathophysiological event in meningitis, results in extravasation of leucocytes into subarachnoid space. The blood-CNS barrier disruption is mediated by primarily two enzyme systems, the plasminogen activators (PAs) and matrix metalloproteinases (MMPs). The present study showed that the activities of tissue-type PA (tPA), urokinase-type activator (uPA) and MMP-9 in cerebrospinal-like fluid (CSF-like fluid) were significantly increased in mice with eosinophilic meningitis compared with uninfected mice. Eosinophilia significantly correlated with tPA, uPA and MMP-9 activities, and albumin concentration. In addition, when GM6001, a specific matrix metalloproteinase blocker, was injected into infected mice, MMP-9 activity and total protein concentrations declined from their preinjection highs. These results suggest that the PAs and MMP-9 proteolytic cascade may be associated with blood-CNS barrier disruption in eosinophilic meningitis caused by Angiostrongylus cantonensis.

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Citations

May 27, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Kanlayanee Sawanyawisuth, Kittisak Sawanyawisuth
May 13, 2008·Experimental Parasitology·Ke-Min ChenJer-Yuh Liu
Feb 11, 2015·Experimental Parasitology·Ling-Yuh ShyuShih-Chan Lai
Jan 9, 2014·International Journal of Molecular Medicine·Ying YuZhaohui Zhang

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