Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
E VairaktarisF W Neukam

Abstract

In light to association of increased platelet glycoprotein Ia (GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C807/T807), affecting the GPIa gene expression, in the development of oral cancer. DNA samples of 110 patients with oral cancer and 114 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis. The mutant T807 allele homozygotes were significantly increased in the group of patients compared to the control group (P < 0.001). Furthermore, significantly increased frequency of mutant alleles compared to controls was observed in the subgroup of patients with a positive history for cancer (P < 0.01). The obtained results indicate that the C807/T807 polymorphism is indeed a genetic predisposing factor which contributes to increased risk for oral cancer.

References

Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·P A AndreasenM J Duffy
May 1, 1997·Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology·A MialheD Seigneurin
Dec 21, 2005·Journal of Cancer Research and Clinical Oncology·E VairaktarisF W Neukam

❮ Previous
Next ❯

Citations

Jun 15, 2007·Journal of Cancer Research and Clinical Oncology·C YapijakisE Patsouris
Oct 3, 2008·European Journal of Human Genetics : EJHG·Liesel M FitzGeraldJoanne L Dickinson
Oct 16, 2008·Journal of Cancer Research and Clinical Oncology·Christos YapijakisEleftherios Vairaktaris
Jun 1, 2012·Cancer Investigation·Jutta RiesEmeka Nkenke
Feb 11, 2015·The Prostate·Suyin Paulynn ChinJoanne L Dickinson
May 15, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E VairaktarisE Patsouris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.