Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand

International Journal of Hygiene and Environmental Health
Suparp KietthubthewWilliam W Au

Abstract

Oral squamous cell carcinoma (OSCC) is highly prevalent in southeastern Asia suggesting that region-specific environmental and biological factors contribute to the development of this cancer. Exposure to oral carcinogens (i.e. betel quid) and pathogenic agents (i.e. papilloma virus) is common among individuals that develop OSCC in countries such as Thailand, India etc. However, not all individuals with such exposures develop the disease suggesting that other factors further increase susceptibility to OSCC. It is therefore plausible that functional variants in DNA repair genes and/or genes controlling inflammation and immunological response play a role in determining susceptibility to OSCC. Previous studies (including ours) have found an association between variants in DNA repair genes and increased susceptibility to OSCC. By extension, the current study examined the association between SNPs in genes encoding proteins involved in inflammation and immunomodulation (IL1alpha, IL1beta, IL8, TNFalpha) and OSCC. A total of 107 cases and 157 controls were analyzed. OSCC cases were more likely to carry the "T" allele at the IL1alpha(+4845) SNP than controls (OR=2.0, 1.0-4.4). OSCC cases that smoke and drink were more likely to carry ei...Continue Reading

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Citations

Dec 5, 2013·International Journal of Cancer. Journal International Du Cancer·Neela GuhaKurt Straif
Jun 27, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Syed A KhurramSimon A Whawell
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Apr 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ziliang WangGong Yang
Jun 16, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lan YangRuolin Li
Sep 7, 2016·Immunologic Research·Carolina Montoya-RuizPaula A Velilla
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Fang-Chun ChenYu-Ying Tang

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