Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population

Gene
Thiago Magalhães da SilvaFabrício Rios-Santos

Abstract

The present study aimed to investigate the association of endothelial nitric oxide synthase (eNOS) gene polymorphisms with primary open angle glaucoma (POAG). We conducted a case-control study that included 90 patients with POAG and 127 healthy controls whose blood samples were genotyped for the functional polymorphisms T-786C and Glu298Asp of the eNOS gene by Taqman fluorescent allelic discrimination assay. The T-786C polymorphism was significantly associated as a risk factor for POAG among women (OR: 2.28; 95% CI: 1.11 to 4.70, p=0.024) and marginally associated to the risk of POAG in the patients ≥52 years of age at diagnosis (OR: 2.11; 95% CI: 0.98 to 4.55, p=0,055). However, these results was not confirmed after adjustments for gender, age, self-declared skin color, tobacco smoking and eNOS genotypes by multivariate logistic regression model (OR: 2.08; 95% CI: 0.87 to 5.01, p=0.101 and OR: 2.20; 95% CI: 0.95 to 5.12, p=0.067, respectively). The haplotype CG of T-786C and Glu298Asp showed a borderline association with risk of POAG in the overall analysis (OR: 1.76; 95% CI: 0.98 to 3.14, p=0.055) and among women (OR: 2.02; 95% CI: 0.98 to 4.16, p=0.052). Furthermore, the CG haplotype was significantly associated with the dev...Continue Reading

References

Feb 1, 1990·The Journal of Clinical Investigation·C Boulanger, T F Lüscher
May 1, 1994·Survey of Ophthalmology·J Flammer
Jun 17, 1998·Journal of the American College of Cardiology·Y ShimasakiK Nakao
Jul 12, 2001·American Journal of Epidemiology·C A HulsmanP T de Jong
Jun 5, 2002·Ophthalmology·Bickol N MukeshHugh R Taylor
Jul 26, 2002·Briefings in Bioinformatics·Cathryn M Lewis
Oct 18, 2002·Genetic Epidemiology·Richard W Morris, Norman L Kaplan
Feb 26, 2003·Clinical Chemistry·Maria Giovanna ColomboAldo Clerico
May 19, 2004·The British Journal of Ophthalmology·F GalassiE Masini
Mar 10, 2005·Journal of Clinical Laboratory Analysis·Hui-Ju LinSeng-Sheen Fan
Aug 27, 2005·Investigative Ophthalmology & Visual Science·Joanne F J LoganSimon J A Rankin
Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Apr 25, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tsutomu SakaiKenji Kitahara
Apr 11, 2007·Archives of Ophthalmology·Kaija PolakLeopold Schmetterer
Mar 18, 2009·Neurologic Clinics·Christine L Lay, Susan W Broner
May 14, 2009·DNA and Cell Biology·Marcelo R LuizonJose E Tanus-Santos
Apr 2, 2010·Investigative Ophthalmology & Visual Science·Bao Jian FanChi Pui Pang

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Citations

Apr 1, 2013·Annals of Neurosciences·Emmanuel S BuysBruce R Ksander
Nov 22, 2013·Japanese Journal of Ophthalmology·Mitsuko Takamoto, Makoto Araie
Apr 9, 2014·American Journal of Ophthalmology·Gilbert T FekeLouis R Pasquale
Jan 1, 2016·Current Opinion in Ophthalmology·Louis R Pasquale
Mar 10, 2016·Seminars in Ophthalmology·Samantha S DewundaraLouis R Pasquale
Jun 7, 2014·Frontiers in Molecular Neuroscience·Emmanuel S BuysBruce R Ksander
May 23, 2018·Menopause : the Journal of the North American Menopause Society·Jae Hee KangLouis R Pasquale
Apr 4, 2020·Scientific Reports·Fiona McDonnellW Daniel Stamer
Oct 25, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hideki ChumanNobuhisa Nao-I
Apr 11, 2018·American Journal of Physiology. Cell Physiology·Fiona McDonnellW Daniel Stamer
Mar 23, 2019·Investigative Ophthalmology & Visual Science·Min ChenKaijun Wang
Sep 7, 2019·Therapeutic Advances in Ophthalmology·Syed Mudassar Imran BukhariLiza-Sharmini Ahmad Tajudin
Jan 6, 2021·Genes·Ryan ZukermanThomas A Ciulla

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