Association of polymorphisms of preptin, irisin and adropin genes with susceptibility to coronary artery disease and hypertension.

Medicine
Haidong WangPei Jiang

Abstract

Preptin, irisin and adropin are 3 new players in energy regulation that are related body mass index, lipids, glucose and insulin levels which may affect incidence of cardiovascular diseases. The aim of the present study was to evaluate eight single nucleotide polymorphisms (SNPs) of preptin genes (rs1003483, rs1004446, rs2239681, rs680, and rs3741204), irisin (rs16835198 and rs3480) and adropin (rs2281997) gene in patients with coronary artery disease (CAD) and hypertension. This case-control study was carried out on 372 volunteers, which were divided into 3 subgroups including: CAD patients with hypertension (CAD+H+), CAD patients with no hypertension (CAD+H-), and non-hypertensive non-CAD subjects as control group (CAD-H-) as health control. Genomic DNA from whole blood was extracted and eight SNPs were assessed using polymerase chain reaction- ligase detection reaction method. A significant difference was found in the genotype and allele frequency of preptin rs1003483 gene in CAD+H+ compared to CAD+H- groups (P = .019 and P = .018, respectively). Allele frequency of rs1003483 was significantly different between CAD+H- groups and healthy control groups (P = .043). There also existed a significant difference the genotype frequ...Continue Reading

References

Jun 24, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Michael Wallis
Nov 17, 2010·Gynecologic Oncology·Monica McGrathImmaculata De Vivo
Jul 13, 2012·The Journal of Endocrinology·Kai-Chun ChengAkio Inui
Nov 13, 2012·Heart·Massimo Mangino, Tim Spector
Jan 30, 2013·Cardiovascular Therapeutics·Ahmet CelikSuleyman Aydin
Sep 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Kyung Hee ParkChristos S Mantzoros
May 28, 2014·International Journal of Endocrinology·María PardoFelipe F Casanueva
Jul 26, 2014·Metabolism: Clinical and Experimental·Grigorios PanagiotouChristos S Mantzoros
Sep 27, 2014·Current Opinion in Cell Biology·D Grahame Hardie
Apr 29, 2015·Heart, Lung & Circulation·Liang-Ping ZhaoXiang-Jun Yang
Jun 4, 2015·Physiological Reports·Eugen BrailoiuG Cristina Brailoiu
Jun 21, 2015·Journal of Pediatric and Adolescent Gynecology·Catalina GranadaPaige Hertweck
Jul 15, 2015·Oman Medical Journal·Farrah A AntonioJoseph M Pappachan
Dec 20, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Liang LiChao-Ke Tang
Mar 15, 2016·JAMA Internal Medicine·Sarah LewingtonUNKNOWN China Kadoorie Biobank Consortium
Mar 22, 2016·Experimental and Therapeutic Medicine·Liang-Ping ZhaoWei-Ting Xu
Jul 21, 2017·The Proceedings of the Nutrition Society·Klaas R Westerterp
Jul 1, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bo LiTao Li
Nov 8, 2018·International Journal of Endocrinology·Ilse Yessabel Martinez MunozJose de Jesus Garduno Garcia

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Citations

Mar 30, 2021·Hormone Molecular Biology and Clinical Investigation·Rasim MogulkocAbdullah Sivrikaya

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SPSS

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